Browse our latest Biochemistry and Chemical Biology articles

Genetic, biochemical, and bioinformatic analyses reveal how expanding metabolic repertoire interferes with fundamental processes like protein synthesis inside cells and the role of D-aminoacyl-tRNA deacylase2 in protecting these processes during terrestrialisation.

Structural, functional, and bioinformatics analyses further understanding of the initial steps of prokaryotic glycoconjugate biosynthesis catalyzed by the large class of membrane-embedded monotopic phosphoglycosyl transferase superfamily.

New P-glycoprotein structures reveal a substrate translocation mechanism and pathway across lipid bilayers that challenges ATP-binding cassette transporter norms.

Disulfide-bridged fibroblast growth factor 2 (FGF2) dimerization at the inner plasma membrane leaflet produces the building block for higher FGF2 oligomers that drive FGF2 membrane translocation into the extracellular space.

Computational analyses and biochemical measurements redefine the mechanisms by which pyrin-only-proteins specifically target and regulate the assembly of inflammasomes.

Native mass spectrometry reveals the thermodynamic basis for high-affinity lipid binding to the ABC transporter MsbA.

Engineering new intrabodies allows to develop selective and non-interfering tools for the visualization of endogenous PSD-95 with advanced imaging techniques.

Alkaloid-binding globulin (ABG) is a novel protein discovered in the plasma of poison frogs that transports many alkaloids, with structural homology to mammalian hormone carriers and amphibian biliverdin-binding serpin.