Richard Sejour, Janet Leatherwood ... Bruce Futcher
The 5' ends of genes are slightly enriched for rare codons largely because the ends turnover in evolution and gather rare codons, and these rare codons do not improve translation.
The articles in this special issue highlight how modern cellular, biochemical, biophysical and computational techniques are allowing deeper and more detailed studies of allosteric kinase regulation.
Carlo Giannangelo, Matthew P Challis ... Darren J Creek
M1 alanyl aminopeptidase is chemically validated as an attractive antimalarial target by confirming the on-target activity of a novel selective inhibitor using chemoproteomics and metabolomics-based drug target deconvolution approaches.
The first structural and biochemical study of the role of the ATP-cone in anaerobic ribonucleotide reductases shows that dATP allosterically prevents transfer of a glycyl radical to the substrate.
Bacterial exonuclease III exhibits underestimated enzymatic activities on single-stranded DNA, which may redefine its roles in relevant biological processes and biosensor development.
A biochemical approach shows co-phase separation of CCL5 with heparan sulfate establishes a specific chemokine concentration gradient for chemotactic activity.
