Browse our latest Biochemistry and Chemical Biology articles

A minimal subset of two to three residues in cyclic nucleotide binding (CNB) domains controls nucleoside vs. cyclic nucleotide specificity, repurposing PKA of certain pathogens for novel nucleoside signaling pathways or sensing.

The extracellular matrix formed during embryonic brain development facilitates the migration of cortical neurons.

A multidisciplinary study reveals the reaction mechanism and transition state of adenosine-N⁶ methyl transfer catalyzed by human METTL3-14, deepening our insight into RNA methyltransferases and paving the way for similar studies on related enzymes.

Molecular and biochemical methods provide the first evidence of toxicity of imidacloprid causing developmental retardation in honeybee larvae, highlighting the potential risks of prolonged exposure to insecticides during animal development.

EZH2 is regulated by a K20-methylation dependent proteolysis and this proteolysis process is negatively controlled by AKT-mediated S21 phosphorylation to establish a methylation-phosphorylation switch to control the PRC2 activity and hematopoiesis.

A genetically encoded fluorescent biosensor reveals temporally resolved changes to aspartate concentration during genetic, pharmacological, and nutritional manipulations.

Noncanonical usage of stop codons in ciliates expands structurally flexible Q-rich domains and coevolves with codon usage biases to avoid triplet repeat disorders mediated by CAG/GTC replication slippage.

Expression of Bisphosphoglycerate mutase, a key enzyme affecting the release of oxygen from hemoglobin, is augmented in the murine placenta challenged by gestational hypoxia in mice while its expression is attenuated in placenta of human FGR.

Deletion of β-catenin in Col2⁺ progenitor cells shifts their commitment from osteoblasts to adipocytes, leading to a full spectrum of disease phenotype of glucocorticoid-induced osteonecrosis of the femoral head in adult mice.