Browse our latest Biochemistry and Chemical Biology articles

Biochemical and cell biology studies reveal that postsynaptic density condensates of neuronal synapses and actin cytoskeletons can directly communicate with each other in a phase separation-dependent manner.

Computational approach shows that the occluded state in GLUT transporters is equivalent to the transition state of soluble enzymes and this has the highest affinity for the substrate sugar.

Computational reaction representations and profile hidden Markov model searches of metagenomics databases can be harnessed to accurately predict bacterial species and enzyme sequences responsible for biotransformations in the human gut microbiome.

cis-membrane insertion of human ATG8 N-terminus facilitates autophagosome membrane expansion independent of autophagic cargo.

A novel signaling system in heart mitochondria in which the byproduct of energy metabolism, CO₂/bicarbonate, acts as the primary signal to tune mitochondrial ATP production while keeping energy supply in tight synchronization with energy consumption.

The physical properties of model coacervate protocells are modulated by the activity of an RNA ligase ribozyme, which confers resistance to growth, surface wetting, and material exchange, establishing a link between RNA sequence and protocell phenotype.

Analysis of the tumor microenvironment reveals that pancreatic tumors experience metabolic stress caused by immune cell degradation of the amino acid arginine, and that pancreatic cancers cope by synthesizing arginine to provide access this amino acid despite low tumor availability.

Transcriptional activation of the orphan nuclear receptor Nurr1 by ligands targeting its heterodimer partner retinoid X receptor alpha (RXRα) occurs through a nonclassical pharmacological mechanism involving ligand-binding domain protein-protein interaction inhibition.

A detailed study of the orphan receptor Nurr1, a regulator implicated in neurodegenerative diseases, reveals a new way for ligands to control their transcriptional activity.