Browse our latest Biochemistry and Chemical Biology articles

Cryo-EM structures reveal GC-C associates with regulatory heat shock proteins similarly to bona fide protein kinases and this can guide the further development of mGC-targeted therapeutics.

Cryo-EM structures and molecular dynamics simulations of Cx43 gap junction channel and hemichannel reveal a putative closed state.

The target-myristoyl switch induced by protein-protein interaction is a novel regulatory mechanism for myristoylated EF-hand calcium-binding proteins, in which target binding facilitates exposure of the myristoyl anchor and the association to the lipid membrane in a calcium-independent manner.

The functional role of novel regulatory mechanism within prototypic oncogenic kinase c-Src is described with particular emphasis on cancer cell migration, invasiveness, oncogenic transformation, and multilevel regulation of Src itself.

Understanding protein kinase regulation by activation loop autophosphorylation depends on a critical assessment of experimental design, execution, and interpretation.

Studying the nutrient composition immediately surrounding pancreatic cancer cells provides new insights into their metabolic properties and how they can evade the immune system to promote disease progression.

Hypoxia does not increase glycolysis in proliferating primary cells and antagonizes the increase in glycolysis caused by activation of hypoxia-inducible factor in normoxia, in part, through activation of MYC signaling pathways.

A road to modulators of the kinase activity and the non-enzymatic functions of Src and IDO1 at once.

Regulation of phosphoinositide 3 kinase (PI3Kγ) is essential in immune function, and stimuli that modulate the dynamics of the PI3Kγ helical domain can activate or inhibit kinase activity.

The endoplasmic reticulum (ER) folding sensor UGGT1 essentially cooperates with the peptide editor TAPBPR to provide quality control of MHC I molecules in the antigen presentation pathway.