Browse our latest Biochemistry and Chemical Biology articles

In vitro and in vivo studies uncovered a molecular link between elevated mitochondrial ceramide levels, coenzyme Q depletion, and insulin resistance.

Why does protein kinase A respond to purine nucleosides in certain pathogens, but not to the cyclic nucleotides that activate this kinase in most other organisms?

Screening repurposed drugs identifies that a clinical stage inhibitor splicing related kinases unexpectedly activates YAP driven transcription in cells.

Biochemical, biophysical, and structural approach to determine the molecular basis of the calcium-sensitive regulation of the Gα chaperone and guanine exchange factor Ric-8A by the neuronal calcium sensor NCS-1.

Self-assembly of bacterial ice nucleation proteins is required for efficient activity and is mediated by electrostatic interactions, creating long and thin fibres.

First 3D-structure and first observation of organized protofilaments of MreB from a Gram-positive bacterium, suggesting a model where ATP drives the formation of dynamic pairs of MreB protofilaments on a lipid surface.

The conformational state of a structural protein in bacteria can vary, depending on the concentration level of potassium ions or the nucleotide bound to it.

Differential agonist-induced phosphorylation of free fatty acid receptor 2 is shown in different tissues of transgenic mice engineered to express variant forms of the human ortholog of the receptor.

Based on two independent methods, mitochondria operate at temperatures up to 15°C hotter than ambient, adjusting their heat production so as to maintain temperature in face of physiological stresses.

Phylogenetic and biochemical analysis reveals crucial role of two substitutions in the α–crystallin domain for development of new functionality of IbpA chaperone after the loss of paralogous IbpB in Erwiniaceae.