Browse our latest Biochemistry and Chemical Biology articles

TIM23 core deficiency specifically impacts the oxidative phosphorylation and the mitochondrial ribosome complexes and, unexpectedly, leads to reduction of plasma membrane voltage-dependent potassium channels in neurons.

Plasmodium parasites have repurposed the heme oxygenase scaffold from its canonical heme-degrading function to fulfill an essential and adaptive role in gene expression within the apicoplast organelle.

Biochemical detection of endogenous, paralog-specific DVL2 complexes, molecular characterization of underlying protein domains and functional evidence for their importance extend the knowledge of Wnt pathway regulation through DVL2 biomolecular condensates.

Poor intracellular availability and diffusion of weakly basic, small molecule drugs can be greatly enhanced by preventing ion trapping in crowded cellular environments.

A rapamycin-induced proximity assay enables rapid identification of optimal E3 ligases for target protein degradation in living cells, streamlining early-stage proteolysis targeting chimera development.

Structure-based designed chalcone and pyrazoline derivatives inhibited the ELF3-MED23 protein-protein interaction, leading to HER2 downregulation and retardation of tumor growth in HER2-positive gastric cancer.

The minimal twister sister (TS)-like self-cleaving ribozymes, revealed by deep mutational scanning, represent some of the very few human/primate ribozymes.