Browse our latest Biochemistry and Chemical Biology articles

Biochemical and structural biological analyses show how bacteria can recognize hormones that control the production of important secondary metabolites such as antiparasitics and antibiotics.

Skd3 (human ClpB) is a potent ATP-dependent mitochondrial protein disaggregase that is activated by the rhomboid protease, PARL, and inactivated by MGCA7-linked mutations.

The structure of the chromatin remodeller CHD4 bound to a nucleosome reveals differences to the known Chd1-nucleosome complex and maps cancer mutations.

CHK2 directly binds the AR to mediate transient suppression of AR activity and thus loss of CHK2 function in prostate cancer increases AR activity, DNA damage response and radiation resistance.

The non-signaling complex formed by Activin A and ACVR1 is operant in vivo and is required to temper the degree of heterotopic ossification in the genetic disorder fibrodysplasia ossificans progressiva.

The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.

SIRT1 deacetylates SIRT6 at K33 to facilitate DNA double-strand breaks-recognition, subsequent expansion and local chromatin remodeling.

Doa10, a membrane-embedded ubiquitin ligase, facilitates the removal of membrane proteins from the endoplasmic reticulum and cooperates with the Cdc48 ATPase in this process.

By analyzing five purified recombinant histone deacetylase complexes and designer acetylated mononucleosome substrates, the molecular basis of the unusual substrate specificity of the CoREST complex was revealed.

A novel toxicophore, a 1H-1,2,3-triazole, has been identified in a wide-number of therapeutically-relevant compounds, including two anti-cancer chemotherapeutics, which inhibits mitochondria function and is mechanistically linked to adverse cardiac-cell events.