Browse our latest Biochemistry and Chemical Biology articles

The small glycine residue in the Cav selectivity filter is an overlooked feature that determines Ca²⁺ selectivity and provides new insight into the Ca²⁺ selectivity mechanism conserved from prokaryotes to eukaryotes.

Chemically distinct opioid ligands promote selective protein recruitment by opioid receptors in intact cells.

Single-molecule observations reveal a mechanism that may be used by multiple competing regulatory proteins to control ribosomal RNA production during rapid bacterial cell growth.

A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms.

GTPase-deficient microtubules are hyper-stable and have longer EB binding regions, demonstrating that EBs bind the GTP cap.

The high-resolution X-ray crystal structure of PLC-γ1 reveals a unifying model for the regulation of the PLC-γ isozymes.

Unique biosensor design and protein-engineering enables direct visualization of the active form of Fyn kinase with high specificity, minimal perturbation and shows cellular signaling to be compartmentalized and pulsatile.

Deletion of one copy of the postsynaptic density protein synGAP in rodents causes an increase in the level of the AMPA receptor auxiliary protein TARP in PSDs only in females.

The tethering complex HOPS employs affinity for each of the 4 SNAREs to catalyze assembly of 3-SNARE intermediates, supporting an immediate burst of membrane fusion triggered by the 4th SNARE.

Inhibitors of seeded propagation of alpha-synuclein may be developed into diagnostics and therapeutics for Parkinson's disease.