Browse our latest Biochemistry and Chemical Biology articles

Cyclin-dependent kinase 5 regulates the circadian clock involving phosphorylation of the PER2 protein.

Outer membrane β-barrel proteins in Gram-negative bacteria are assembled within the lumen of the BamA β-barrel.

Post-translational modifications regulate transient protein-protein interactions to disrupt Ubiquitin enzyme/ligase complexes, a strategy used by Shigella to inactivate the host immune response.

Relying on RNA fragments derived from degradation or partial template copying, non-enzymatic primer extension with strand displacement offers a novel and prebiotically plausible approach to RNA self-replication.

Profilin release from the filament end controls the speed of actin growth at physiological conditions.

The pseudokinase-like Legionella effector SidJ catalyzes the glutamylation of bacterial ubiquitin ligases in a calmodulin-dependent manner.

Sterol kinetics and cell-based assays reveal a heretofore unknown step in cholesterol trafficking through the endolysosomal compartment, involving a direct functional interaction between NPC2 and lysosbisphosphatidic acid.

PPM1H protein phosphatase dephosphorylates Rab proteins modulating LRRK2 signalling.

Aβ inhibitors effectively block its aggregation, while also reducing seeding of tau aggregation from Aβ, tau, and AD derived fibrils, suggesting the two share a structurally related disease relevant interface.

A facile method is implemented to modify membrane proteins with biophysical reporters using cysteine-independent approaches in live cells.