The phosphorylation of tyrosine in the heptad repeat of the C-terminal domain of the largest subunit of RNA polymerase II promotes Ser2 phosphorylation by P-TEFb for pausing release.
Modular tetravalent antibodies can be engineered to stimulate signaling through any combination of Frizzled and LRP receptors to drive organoid growth and mobilize endogenous stem cells in vivo.
Crystal structures provide structural rationales for the transport stoichiometry of the gastric proton pump, which suffices the energy requirement for the generation of a million-fold proton gradient across the membrane.
Johann Mignolet, Guillaume Cerckel ... Pascal Hols
A new cell–cell communication system in Streptococcus salivarius, a human gut commensal, discriminates between close signaling molecules to specifically produce bacteriocin-based antimicrobials and disconnects it from foreign DNA acquisition.
Kanokwan Champasa, Caitlin Blank ... Stephen P Bell
Analysis of an essential motif in Mcm4 provides insights into replicative helicase double-hexamer formation and the first step requiring this intermediate during replication initiation.
Travis J Morgenstern, Jinseo Park ... Henry M Colecraft
A novel engineered protein that uncouples electrical signals from downstream biological responses in excitable cells provides a unique investigative tool with potential therapeutic applications.
