Abril Angélica Escamilla-Ayala, Ragna Sannerud ... Wim Annaert
Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
Trafficking of optogenetic tools to primary cilia using nanobodies allows to study cAMP signaling with spatial and temporal resolution independent of the cell body.
In yeast, a fluorescent vacuolar cargo departs from Golgi cisternae early in the TGN stage of maturation, and traffic from prevacuolar endosomes to the vacuole apparently involves a kiss-and-run mechanism.
Combined fate mapping and genetic deletion studies reveal that PDGFRα+ cells and PDGFRα gene itself are required for adipose tissue development but not for adult tissue homeostasis.
André M Lazar, Roshanak Irannejad ... Mark Von Zastrow
An adenylyl cyclase isoform is shown to dynamically traffic to endosomes after activation by G protein in mammalian cells, contributing to cellular cAMP signaling by internalized GPCRs.
Emma J Fenech, Federica Lari ... John C Christianson
Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
The non-signaling complex formed by Activin A and ACVR1 is operant in vivo and is required to temper the degree of heterotopic ossification in the genetic disorder fibrodysplasia ossificans progressiva.
Genetic and electrophysiological analyses reveal calcium-triggering mechanisms for dopamine release in the striatum that may enable fast and slow dopamine coding.
Doa10, a membrane-embedded ubiquitin ligase, facilitates the removal of membrane proteins from the endoplasmic reticulum and cooperates with the Cdc48 ATPase in this process.
