Matthew Richard Johnson, Roxan Amanda Stephenson ... Michael Andreas Welte
In early Drosophila embryos, histone H2Av continuously exchanges between cytoplasmic lipid droplets, a process that modulates H2Av import into nuclei and constitutes a novel post-translational strategy to regulate nuclear H2Av levels.
Nikolay Burnaevskiy, Shengying Chen ... Matt Kaeberlein
Morphological and functional rejuvenation upon exit from adult reproductive diapause in C. elegans is independent of germline signaling, but instead involves somatic nucleolar activation and expansion of the RNA pool.
Tae Yeon Yoo, Jeong-Mo Choi ... Daniel J Needleman
Quantitative experiments and theory show that the tension-dependent regulation of NDC80 binding to kinetochore microtubules arises from a combination of the changing Aurora B concentration at NDC80 and the nonlinearity of Aurora B autoactivation.
Yara E Sanchez-Corrales, Guy B Blanchard, Katja Röper
Quantitative analysis in quasi-3D reveals apically driven cell behaviours that are closely coordinated across the tissue to allow ordered tube invagination through a focal point.
Yeast cell size homeostasis is not controlled by a G1-specific mechanism alone but is likely to be an emergent property resulting from the integration of several mechanisms that coordinate cell and bud growth with division.
QuantEv is a fully automatic and semi-parametric method that allows quantitative analysis of the spatio-temporal distribution of complex molecular trafficking objects at the scale of the whole cell.
During viral assembly, ESCRTIII and VPS4 are recruited after most of the HIV-1 membrane is bent but disappear prior to scission of the virion from the cell.
Dynein-dependent microtubule-cortex interactions – "side-on" versus "end-on" pulling – are regulated by cortical ER and mediated by distinct pools of cortical anchor that are differentially localized along the cell periphery.
