The stimulation of lipopolysaccharides induced nuclear localization of IRAK2 to facilitate nuclear export of a specific subset of inflammation-related messenger RNAs for translation in murine macrophages.
Analysis of a variant without lysine in the intracellular domain reveals a ubiquitylation-independent signalling activity of the DSL ligand Delta and novel functions of the Neuralized and Mindbomb1 E3-ligases during Notch signalling.
Felix Spira, Sara Cuylen-Haering ... Daniel W Gerlich
Asymmetric tension increase along the cell equator promotes self-organization of actomyosin into a partially aligned network during cytokinetic cleavage furrow ingression of vertebrate cells.
The activation of beige adipocyte thermogenesis by cold temperatures and β3-adrenergic receptor agonists induce beige adipocyte formation, function and perdurance.
Manuel Alonso Y Adell, Simona M Migliano ... David Teis
Quantitative 3D lattice light sheet microscopy of unperturbed cells combined with electron tomography and acute loss of function experiments reveals how dynamic ESCRT-III/Vps4 assemblies succeed in reverse membrane budding on endosomes.
Lukas Franz Mager, Viktor Hendrik Koelzer ... Philippe Krebs
ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1-specific GPR137 isoforms.
The mechanism is revealed that connects the protein degradation machinery to cellular membrane-bound compartments during proteostasis stress in mammalian cells.
Nicole Ann Najor, Gillian Nicole Fitz ... Kathleen Janee Green
A protein interaction screen revealed desmosomes as a scaffold for the COP9 de-neddylating complex, to promote epidermal differentiation by governing the balance of Nedd8 and Ubiquitin modifications on Epidermal Growth Factor Receptor.
