Browse our latest Cell Biology articles

Page 238 of 333
    1. Cell Biology

    COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

    Peng Xu, Hannah M Hankins ... Todd R Graham
    COPI vesicle coat protein recognizes a ubiquitin sorting signal on an exocytic v-SNARE to mediate recycling.
    1. Cell Biology
    2. Ecology

    Quantitative 3D-imaging for cell biology and ecology of environmental microbial eukaryotes

    Sebastien Colin, Luis Pedro Coelho ... Colomban de Vargas
    Three-dimensional fluorescence imaging of microbial eukaryotes in environmental samples allows accurate automated taxonomic profiling and quantitative data about ultrastructures and interactions of organisms.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Dynamics of the IFT machinery at the ciliary tip

    Alexander Chien, Sheng Min Shih ... Ahmet Yildiz
    During intraflagellar transport (IFT), kinesin-II dissociates from IFT trains at the flagellar tip and its diffusion in flagella serves as a negative feedback mechanism that facilitates flagellar length control in Chlamydomonas.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Intraflagellar transport: Trainspotting in a cilium

    Dhivya Kumar, Stephen M King
    A new imaging technique sheds light on how cilia regulate their length and growth.
    Version of Record
    Insight
    1. Cell Biology

    Uncoupling of dynamin polymerization and GTPase activity revealed by the conformation-specific nanobody dynab

    Valentina Galli, Rafael Sebastian ... Aurélien Roux
    Uncoupling of dynamin polymerization and GTPase activity can be induced with dynamin, which allows in vivo visualization of its activity at endocytic pits.
    1. Cell Biology

    Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

    Li Zhang, Prashant Rajbhandari ... Peter Tontonoz
    The E3 ubiquitin ligase RNF145 is shown to contribute to crosstalk between the LXR and SREBP-2 pathways in the regulation of cholesterol homeostasis.
    1. Cancer Biology
    2. Cell Biology

    Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism

    William Putzbach, Quan Q Gao ... Marcus E Peter
    Loading of CD95 and CD95L-derived sequences into the RNA-induced silencing complex elicits a distinct form of RNAi-mediated cell death of cancer cells that results from the targeting of multiple survival genes.
    1. Cell Biology

    Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells

    Jennifer T Wang, Dong Kong ... Tim Stearns
    Deletion of delta-tubulin or epsilon-tubulin in human cells results in loss of centriolar triplet microtubules and defects in centriole structure and inheritance.
    1. Cell Biology

    Regulated Ire1-dependent mRNA decay requires no-go mRNA degradation to maintain endoplasmic reticulum homeostasis in S. pombe

    Nicholas R Guydosh, Philipp Kimmig ... Rachel Green
    A critical component of the cellular response to unfolded proteins is the widespread rescue of ribosomes that stall on endonucleolytically-cleaved mRNA transcripts.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

    Tony Ly, Arlene Whigham ... Angus I Lamond
    A detailed analysis of protein abundance and phosphorylation changes across mitotic subphases and interphase in asynchronously growing human cells has been enabled by combining FACS with quantitative MS-based proteomics.