Browse our latest Cell Biology articles

Page 253 of 318
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk

    Daniela Justa-Schuch, Maria Silva-Garcia ... Ruth Geiss-Friedlander
    Cleavage of Syk, a central kinase in B-cell signalling, by DPP9 leads to Syk degradation, identifying novel roles for DPP9 in Syk signaling and in the N-end rule pathway.
    1. Cell Biology

    Seipin is required for converting nascent to mature lipid droplets

    Huajin Wang, Michel Becuwe ... Robert V Farese Jr
    Seipin oligomers dynamically interact with small, nascent lipid droplets near the endoplasmic reticulum to convert them into larger, mature lipid droplets in a newly identified step of lipid droplet formation.
    1. Cell Biology

    Tetherin is an exosomal tether

    James R Edgar, Paul T Manna ... Margaret S Robinson
    Blocking acidification causes endosomes to fuse with the plasma membrane, releasing exosomes that remain attached to the cell surface via the anti-viral protein tetherin.
    1. Cell Biology
    2. Immunology and Inflammation

    Acute exposure to apolipoprotein A1 inhibits macrophage chemotaxis in vitro and monocyte recruitment in vivo

    Asif J Iqbal, Tessa J Barrett ... Edward A Fisher
    Mechanistic insights show how treatment with apoA1 is anti-inflammatory by rapidly disrupting macrophage chemotaxis and monocyte recruitment.
    1. Developmental Biology
    2. Cell Biology

    Cells must express components of the planar cell polarity system and extracellular matrix to support cytonemes

    Hai Huang, Thomas B Kornberg
    Different cytoneme types require specific heparan sulfate proteoglycans (HSPGs) that are stratified within the extracellular matrix in Drosophila.
    1. Cell Biology
    2. Developmental Biology

    In vivo genetic dissection of tumor growth and the Warburg effect

    Cheng-Wei Wang, Arunima Purkayastha ... Utpal Banerjee
    A Drosophila tumor model reveals how the activation of an oncogenic pathway can lead to both tumor growth and a reprogramming of metabolism known as the Warberg effect.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

    Min-Kyung Sung, Tanya R Porras-Yakushi ... Raymond J Deshaies
    Tom1 is the ubiquitin ligase in yeast that anchors a protein quality control pathway that rapidly eliminates ribosomal proteins that fail to assemble into ribosomes.
    1. Cell Biology

    An alternative splicing program promotes adipose tissue thermogenesis

    Santiago Vernia, Yvonne JK Edwards ... Roger J Davis
    NOVA pre-mRNA spacing factors suppress adipose tissue energy expenditure.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes

    Olena Pylypenko, Tobias Welz ... Eugen Kerkhoff
    Components of a Spir:MyoV:Rab11 complex are recruited synergistically to coordinate actin tracks generation and myosin motor activity in vesicle transport processes.
    1. Cell Biology

    QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease

    Virginia Guarani, Claude Jardel ... Manuel Schiff
    Building on previous work (Guarani et al., 2015), MICOS (mitochondrial contact site) assembly and cristae junction formation are shown to have a critical role in human health.