A newly discovered membrane structure associates with one of the centrioles and affects two important centrosomal events in epidermal cells – ciliary positioning and spindle orientation – through a physical interaction.
Richard Panayiotou, Francesc Miralles ... Richard Treisman
G-actin binding controls the susceptibility of MRTF-A to phosphorylation, which works in concert with multiple NES elements to regulate MRTF-A subcellular localisation and activity.
Daniel N Itzhak, Stefka Tyanova ... Georg HH Borner
A spatial proteomics method can capture physiological protein subcellular localization changes in response to a stimulus, resolving all major organelles.
Maximilian Joesch, David Mankus ... Joshua R Sanes
A new pipeline of electron microscopy techniques reduces the time required to visualize genetically targeted neurons and their connections by two orders of magnitude.
Orphan ATM kinase-domain missense mutations are unexpectedly common and form a potent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.