A Drosophila tumor model reveals how the activation of an oncogenic pathway can lead to both tumor growth and a reprogramming of metabolism known as the Warberg effect.
Min-Kyung Sung, Tanya R Porras-Yakushi ... Raymond J Deshaies
Tom1 is the ubiquitin ligase in yeast that anchors a protein quality control pathway that rapidly eliminates ribosomal proteins that fail to assemble into ribosomes.
Components of a Spir:MyoV:Rab11 complex are recruited synergistically to coordinate actin tracks generation and myosin motor activity in vesicle transport processes.
Building on previous work (Guarani et al., 2015), MICOS (mitochondrial contact site) assembly and cristae junction formation are shown to have a critical role in human health.
Two sets of modular components are sufficient to rewire MAPKs to regulate proteins through ubiquitination – a complementary pair of protein interaction domains and a phosphodegron.
Yilin Kang, Michael James Baker ... Diana Stojanovski
A novel and metazoan-specific protein, Tim29, is identified as a subunit of the human TIM22 complex and shown to function in the assembly of hTim22 and facilitate contacts with the TOM complex.
