Rupa Banerjee, Christina Gladkova ... Dejana Mokranjac
Two domains of the peripheral membrane protein Tim44 interact with two different sectors of a translocase to coordinate the translocation of proteins across the inner mitochondrial membrane.
Hamdah Shafqat-Abbasi, Jacob M Kowalewski ... Staffan Strömblad
“Discontinuous” and “Continuous” migration modes are divergent mesenchymal migration strategies that arise spontaneously in parallel in an equilibrium modulated by cell-matrix attachment and actomyosin contractility.
Marina Theodosiou, Moritz Widmaier ... Reinhard Fässler
Kindlin-2 co-operates with talin to activate fibronectin-binding integrins on fibroblasts and subsequently induces cell spreading by recruiting paxillin to small, peripheral nascent adhesions.
Joaquim Grego-Bessa, Joshua Bloomekatz ... Kathryn V Anderson
In addition to its role in regulating proliferation and cell death, the PTEN tumor suppressor regulates epithelial morphogenesis through the PDK1 kinase.