Richard Panayiotou, Francesc Miralles ... Richard Treisman
G-actin binding controls the susceptibility of MRTF-A to phosphorylation, which works in concert with multiple NES elements to regulate MRTF-A subcellular localisation and activity.
Daniel N Itzhak, Stefka Tyanova ... Georg HH Borner
A spatial proteomics method can capture physiological protein subcellular localization changes in response to a stimulus, resolving all major organelles.
Maximilian Joesch, David Mankus ... Joshua R Sanes
A new pipeline of electron microscopy techniques reduces the time required to visualize genetically targeted neurons and their connections by two orders of magnitude.
Orphan ATM kinase-domain missense mutations are unexpectedly common and form a potent oncogenic event and a biomarker for Topo-isomerase I inhibitor based therapy.
Catherine A Hartzell, Katarzyna I Jankowska ... Richard S Lewis
By restricting actin polymerization to the perimeter of the immune synapse and promoting depolymerization, calcium influx drives centripetal actin flow, which confines CRAC channels and the endoplasmic reticulum to the synapse center.