Browse our latest Cell Biology articles

Page 272 of 318
    1. Cell Biology

    Interplay between kinesin-1 and cortical dynein during axonal outgrowth and microtubule organization in Drosophila neurons

    Urko del Castillo, Michael Winding ... Vladimir I Gelfand
    Cortical dynein organizes unipolar microtubule arrays in Drosophila axons by expelling minus-end-out microtubules.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

    Steffen Preissler, Cláudia Rato ... David Ron
    Attaching a molecule of adenosine mono-phosphate (AMP) to the BiP protein at threonine 518 regulates its chaperone activity in the endoplasmic reticulum.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

    Zhe Ji, Ruisheng Song ... Kevin Struhl
    Thousands of "noncoding" RNAs, 5' "untranslated" regions, and pseudogenes in humans are actually translated, and some of these are likely to express functional proteins.
    1. Cell Biology

    Transmembrane chemokines act as receptors in a novel mechanism termed inverse signaling

    Kirsten Hattermann, Henrike Gebhardt ... Rolf Mentlein
    In a new mechanism of cellular communication termed “inverse signaling", a transmembrane chemokine acts as a "receptor" for its previously shed form.
    1. Cell Biology
    2. Developmental Biology

    Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity

    Bart-Jan de Kreuk, Alexandre R Gingras ... Mark H Ginsberg
    The proteins Heart of Glass (HEG1) and Rasip1 are both essential for cardiovascular development; and directly bind to each other to guide Rasip1 to endothelial cell junctions to support vascular integrity.
    1. Cell Biology

    Discrete spatial organization of TGFβ receptors couples receptor multimerization and signaling to cellular tension

    Joanna P Rys, Christopher C DuFort ... Tamara N Alliston
    Cells control the spatial organization and signaling of TGFβ receptors at focal adhesions via a mechanically regulated mechanism to integrate biochemical and physical cues.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system

    Daichao Xu, Bing Shan ... Junying Yuan
    Akt can regulate the ubiquitin-proteasome system by mediating phosphorylation and activation of USP14, which may have implications in the control of global proteostasis by growth factors and in tumorigenesis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response

    Xing-Huang Gao, Dawid Krokowski ... Maria Hatzoglou
    ATF4, the master regulator of transcription during the Integrated Stress Response (ISR), causes global changes in cysteine sulfhydration of proteins and this event causes cellular metabolic reprogramming.
    1. Cell Biology

    Greatwall promotes cell transformation by hyperactivating AKT in human malignancies

    Jorge Vera, Lydia Lartigue ... Anna Castro
    Greatwall is a new oncogene that induces AKT hyperphosphorylation by promoting the degradation of the phosphatase PHLPP.
    1. Cell Biology
    2. Immunology and Inflammation

    ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

    Charlotte Lässig, Sarah Matheisl ... Karl-Peter Hopfner
    Mutations within the ATPase domain of RIG-I in patients with Singleton-Merten Syndrome prevent ATP-hydrolysis dependent dissociation of RIG-I from double-stranded RNA and lead to unintentional constitutive signaling through increased binding of endogenous RNA.