Browse our latest Cell Biology articles

Page 275 of 318
    1. Cell Biology
    2. Developmental Biology

    Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma

    Simone Hettmer, Anna C Schinzel ... Amy J Wagers
    The availability of asparagine is important for cell growth and nascent peptide synthesis in certain sarcoma cells, and could be targeted therapeutically to inhibit tumor growth.
    1. Cell Biology
    2. Neuroscience

    A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

    Philippe FY Vincent, Yohan Bouleau ... Didier Dulon
    A synaptic F-actin network tightly controls the flow of synaptic vesicles during exocytosis at the inner hair cell ribbons.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain

    L Shahul Hameed, Daniel A Berg ... András Simon
    Control of neural stem cells by reactive oxygen species (ROS) provides a link between systemic shifts in oxygen tension and neuronal regeneration, and suggests an evolutionary driving force for the inherent ability of newts to regenerate their brain cells.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: Hold your breath!

    Katharina Lust, Joachim Wittbrodt
    Version of Record
    Insight
    1. Cell Biology
    2. Computational and Systems Biology

    Self-establishing communities enable cooperative metabolite exchange in a eukaryote

    Kate Campbell, Jakob Vowinckel ... Markus Ralser
    A eukaryotic cell model overcomes metabolic deficiencies within a complex, self-establishing community that enables the growth-relevant exchange of metabolic intermediates.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Precise let-7 expression levels balance organ regeneration against tumor suppression

    Linwei Wu, Liem H Nguyen ... Hao Zhu
    Mouse genetic studies reveal that let-7 performs potent tumor suppressive roles, but at the expense of regeneration and tissue homeostasis in the liver, findings with unanticipated therapeutic implications.
    1. Cell Biology

    Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly

    Sari Tojkander, Gergana Gateva ... Pekka Lappalainen
    Mechanosensitive inhibition of actin polymerization through VASP phosphorylation is required for stress fiber maturation and alignment.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

    Elisabeth A Geyer, Alexander Burns ... Luke M Rice
    A buried mutation in αβ-tubulin reveals an allosteric response to GDP in the lattice that dictates microtubule catastrophe and shrinking.
    1. Cell Biology

    Ion channels and calcium signaling in motile cilia

    Julia F Doerner, Markus Delling, David E Clapham
    Direct patch clamp of ependymal motile cilia reveals that voltage-gated calcium channels in the cell body dominate their electrical and calcium signaling properties.
    1. Cell Biology
    2. Developmental Biology

    Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

    Amanda D Yzaguirre, Arun Padmanabhan ... Jonathan A Epstein
    Ras-GAP activity suppresses the hemogenic potential of the embryonic heart.