Kimberly C Tu, Li-Chun Cheng ... Alejandro Sánchez Alvarado
The dynamic homeostasis of the planarian epidermis serves as an experimental paradigm to study stem cell dynamics and post-mitotic specification of diverse functional cell fates.
The B-1a cell heavy chain antibody repertoire differs dramatically from the follicular and marginal zone B cell repertoire and is defined by distinct mechanisms driven by self antigens rather than antigens derived from the microbiota.
Oligomerization of p62/SQSTM1 generates high avidity binding regions that enable it to spatially select for concentrated ubiquitin and ATG8-family proteins.
The secreted molecules FAM150A and FAM150B bind to the ALK RTK extracellular domain, potently activating the receptor activation and driving downstream signaling events.
The ability of tumors to respond to nutritional signals is mediated by Salt-inducible kinases, which ensure tumor growth under nutrient-rich conditions including obesity.
Agnieszka Konopacka, Mingkwan Greenwood ... David Murphy
Caprin-2 is up-regulated in the rat hypothalamus by osmotic stress and controls vital homeostatic osmoregulatory mechanisms by altering the length of the poly(A) tail on arginine vasopressin mRNAs.
Building on previous work (Conduit et al., 2014), and contrary to what was previously thought, it is shown that key centrosomal proteins are not recruited to centrosomes as part of large multi-protein assemblies.
Deletion of one gene can lead to inactivation of other genes which restore a perturbed cellular function but change the epistatic interactions and the dynamics of the responsible module.
