Gαq stimulates HDAC5 phosphorylation by PKC-independent PKD/PKCμ activation to induce the IκB expression and limit the NF-κB-mediated inflammatory response which essential for proper endometrial decidualization and early pregnancy.
The BABY algorithm by estimating growth rates of individual cells from time-lapse microscopy images will help characterise the diversity in populations of budding cells, particularly differences in fitness.
A survey of oxygen-dependent enzymes suggests new candidates for oxygen sensors, expanding potential mechanisms underlying hypoxia-related adaptations or diseases in humans.
Melanocortin 1 receptor (MC1-R) deficiency in hepatocytes increases cholesterol levels in the circulation and liver in mice, while selective activation of MC1-R reduces cellular cholesterol content in cultured hepatocytes.
A genetic screen identifies a lipid pathway which impacts the endoplasmic reticulum unfolded protein response and highlights a mechanism through which lipid disequilibrium might facilitate the progression of proteopathic diseases.
Tylor R Lewis, Sebastien Phan ... Vadim Y Arshavsky
Maturation of light-sensitive 'disc' membranes in vertebrate photoreceptors requires a precise balance between their content of the visual pigment rhodopsin forming the disc body and tetraspanin proteins forming the disc rim.
Lenka Koudelková, Markéta Pelantová ... Daniel Rösel
The functional role of novel regulatory mechanism within prototypic oncogenic kinase c-Src is described with particular emphasis on cancer cell migration, invasiveness, oncogenic transformation, and multilevel regulation of Src itself.
