Macropinocytosis of the signalling receptor LPAR1, by an actin and CYRI-B-dependent mechanism, impacts on progression and spread of pancreatic cancer in a mouse model.
Actin-independent water influx complements actin-driven cytoskeletal forces to potentiate chemoattractant-induced migration in primary human neutrophils.
Nicolas Loyer, Elizabeth KJ Hogg ... Jens Januschke
PAR-3/Baz function is regulated by CDK1 in asymmetrically dividing cells in the central and peripheral nervous system of Drosophila revealing direct regulation of cell polarity by the cell cycle machinery in the context of cell fate specification.
Posttranslational modifications of tubulins regulate axonal growth and regeneration by controlling the stabilities of microtubules or modulating their interactions with microtubule-associated proteins.
A biochemical approach shows co-phase separation of CCL5 with heparan sulfate establishes a specific chemokine concentration gradient for chemotactic activity.
