Genetic analysis of Hippo pathway kinases in a close unicellular relative of animals suggests an ancestral role of this ancient pathway in regulating cytoskeletal dynamics and density of multicellular aggregates.
Wayne Mitchell, Ludger JE Goeminne ... Vadim N Gladyshev
Partial chemical reprogramming is able to reduce the biological age of cells by diverting them to a different metabolic state marked by a strong upregulation of mitochondrial oxidative phosphorylation.
Mina O Seedhom, Devin Dersh ... Jonathan W Yewdell
Quantitative protein and ribosome 'accounting' in T cells highlights a gap in our understanding of how activated T cells sufficiently replicate their proteome during rapid cell division driven by infection.
Martin Wohlwend, Pirkka-Pekka Laurila ... Johan Auwerx
CERS1 reduction in aging skeletal muscle contributes to impaired muscle function, myogenesis and increases inflammation and fibrosis, highlighting the significance of very long chain ceramides in age-related muscle homeostasis.
Spatiotemporal mapping of a variety of proteins in and around the Golgi apparatus in budding yeast was performed using super-resolution live imaging microscopy and identified the ER-Golgi intermediate compartment that matures into the Golgi.
WRNIP1 has been identified as a pivotal factor in preventing the pathological persistence of R-loop-induced transcription-replication conflicts and the accumulation of DNA damage, thereby ensuring genome integrity.
A brown-to-white adipogenic transdifferentiation process in the periureter region of mouse renal adipose tissue gives rise to a population of cold-inducible adipocytes with a transcriptome distinct from subcutaneous beige adipocytes.
