The cooperative action of PAF15 deubiquitylation by USP7 and its dissociation from chromatin by ATAD5 regulates proper PAF15Ub2 signaling termination, which is important for replication and maintenance of DNA methylation.
Christa Ringers, Stephan Bialonski ... Nathalie Jurisch-Yaksi
Novel frequency-based analysis and computation modeling of cilia carpets reveals that tissue-scale metachronal coordination of cilia can arise even in the absence of global synchronization.
Proximity proteomics combined with mouse genetics are used to assess the composition of active zone-like sites for dopamine release and reveal that the scaffolding protein RIM organizes these sites.
Marco Caligaris, Raffaele Nicastro ... Claudio De Virgilio
Discovery of new Snf1/AMPK targets in the TORC1 pathway highlights the complex, multilayered crosstalk between major signaling pathways in the regulation of nutrient deprivation sensing.
Patryk Slusarczyk, Pratik Kumar Mandal ... Katarzyna Mleczko-Sanecka
A decline in iron-recycling functions of the splenic red pulp macrophages early during aging is driven by iron loading and involves their damage and a loss in red blood cell clearance capacity.