Browse our latest Cell Biology articles

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    1. Cell Biology
    2. Immunology and Inflammation

    Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10

    Ana J Caetano, Yushi Redhead ... Paul T Sharpe
    Integrated single-cell and spatial genomics provides the first molecular map of the human oral mucosa and reveals a novel pro-inflammatory fibroblast involved in disease progression.
    1. Cell Biology
    2. Developmental Biology

    Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration

    Eunjin Cho, Xiangguo Che ... Tae-Hoon Lee
    Peroxiredoxin 5 contributes to the maintenance of bone homeostasis by regulating osteoblast differentiation.
    1. Cell Biology
    2. Neuroscience

    Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons

    Emma T Watson, Michaela M Pauers ... Edwin R Chapman
    Using carefully controlled expression levels and a variety of optical pulse-chase assays in mammalian neurons, an updated model for the polarized transport of synaptic vesicle proteins, and the first steps of synaptic vesicle biogenesis, were uncovered.
    1. Cell Biology

    Testing the ion-current model for flagellar length sensing and IFT regulation

    Hiroaki Ishikawa, Jeremy Moore ... Wallace F Marshall
    A model for flagellar length control based on calcium influx is rejected based on quantitative measurements in Chlamydomonas cells.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Structures of human dynein in complex with the lissencephaly 1 protein, LIS1

    Janice M Reimer, Morgan E DeSantis ... Andres E Leschziner
    Structures of human cytoplasmic dynein-1 bound to its regulator LIS1 reveal the interfaces involved in forming the complex and provide a context for disease-linked mutations.
    1. Cell Biology

    A CRISPR screen in intestinal epithelial cells identifies novel factors for polarity and apical transport

    Katharina MC Klee, Michael W Hess ... Lukas A Huber
    Applying a CRISPR knockout screen in polarized intestinal epithelial cells and subsequent phenotypic analyses identified various genes, of which several were previously not associated with epithelial homeostasis, to be relevant for proper epithelial polarization, apical cargo transport, and endo/lysosomal morphology.
    1. Cell Biology

    Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue

    Theodore J Zwang, Rachel E Bennett ... Bradley T Hyman
    Conditions for multiplexed antibody labeling in mouse brain tissue translates to effective labeling in human brain tissue when samples are prepared similarly.
    1. Cell Biology
    2. Genetics and Genomics

    T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation

    Alexandro Landshammer, Adriano Bolondi ... Alexander Meissner
    Discovery of a novel long non-coding RNA overlapping the distal SOX17 enhancer (eSOX17) that plays an essential role in human endoderm development.
    1. Cell Biology
    2. Neuroscience

    Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders

    Lydie Burglen, Evelien Van Hoeymissen ... Joris Vriens
    Newly identified gain-of-function variants indicate TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures

    Nazir M Khan, Martha Elena Diaz-Hernandez ... Hicham Drissi
    The iPSCs derived from OA cartilage showed memory of disease which affect its chondrogenic potential and regulation at epigenetic and metabolic level may be used to control the regenerative potential of these iPSCs.