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A new role for Endonuclease G with respect to the generation of mtDNA deletions is identified, which is dependent on the formation of G4 DNA within human mitochondria.

Mice made obese by feeding a high starch diet do not develop insulin resistance like mice made similarly obese by a high fat diet and this is associated with differences in specific bioactive ceramide species in liver and muscle tissue.

SIMC1 and SLF1 bind exclusively to SLF2 to form two separate complexes that direct the human SMC5/6 complex to its antiviral defense or DNA lesion repair activities.

Quantitative imaging of neurons reveals how opioid agonists produce long-term functional tolerance at presynaptic terminals through rapid internalization of receptors from the axonal surface.

When non-glycosylated, Seipin, which spans the endoplasmic reticulum (ER) membrane twice, forms aggregates in an oligomerization-dependent manner, distorts the shape of the ER, and incorporates SERCA2b via direct interaction, inactivation of which results in induction of ER stress and apoptosis.

A large proportion of nanobodies are unstable when expressed intracellularly, but can be reliably stabilized for intracellular expression by applying a generalizable mutagenesis strategy based on positional sequence conservation.

Two modes of GPCR endocytosis by β-arrestin are differentially coupled to downstream signaling.

Partial ablation of osteocytes alters lineage cell specifications in bone and bone marrow, resulting in the acceleration of skeletal aging.

Counterintuitively, activation of the transcriptional repressor of growth-promoting genes is important for yeast cell acclimation to salt stress, such that cells with larger activation of the repressor tend to have faster growth acclimation after stress.

Profiling the adipocyte secretome reveals LRG1 as a novel adipokine that promotes insulin sensitivity and modulates inflammation triggered by release of cytochrome c from dead/dying cells, describing a new pathway at the intersection of obesity and its systemic sequelae.