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Proteins pivotal to epithelial polarization organize in separated clusters, simplifying the current view by showing that a small fraction of the many protein–protein interactions proposed are prominent in mature epithelia.

Mettl3 post-transcriptionally reduces Fgf16 mRNA levels through an m⁶A-Ythdf2-dependen pathway, thereby controlling cardiomyocyte proliferation and heart regeneration.

High-resolution imaging of microglia in zebrafish reveals a rate-limiting role for the centrosome in the engulfment of apoptotic neurons during brain development.

The first quantitative live-cell microscopy this work shows depicting the order of events preceding secretion in budding yeast.

β-catenin, a key effector of the Wnt signaling pathway, is transported into the nucleus via a direct interaction between its PY-NLS and TNPO1 offering new potential targets for cancer therapeutics.

A new method using a motorised ultramicrotome and open-source software allows semi-automatic targeting of regions of interest for electron microscopy.

Biochemical and genetic approaches revealed a posttranslational mechanism controlling the abundance of SUN2, a critical nuclear envelope protein.

Locally activatable bioluminescence (LABL) is a genetically encoded reporter that allows real time, in vivo measurement of distinct clocks in different cells and tissues in Drosophila.

The anchoring properties of Ca_V β2 subunits to the plasma membrane determine the biophysical states of Ca_V2.2 channels by regulating PIP₂ coupling to the nonspecific phospholipid-binding site in the I–II loop.

Animal models reveal that mitochondrial complex I is dispensable for homeostatic functions of the mouse liver.