Browse our latest Chromosomes and Gene Expression articles

DNA replication fork rate in budding yeast is regulated in response to DNA damage by phosphorylation of two proteins, Mrc1 and Mcm10, by the Rad53 protein kinase.

Interaction of the MLL and HBO1 complexes is a key nexus for leukemic transformation that can serve as a therapeutic target.

A structural and biochemical approach shows that CTP binding and hydrolysis regulate nucleation, spreading, and recycling of a chromosome segregation protein ParB.

GapR-seq enables the global mapping of positive supercoiling in bacteria and yeast, revealing positive supercoils downstream of highly expressed genes and, in yeast, associated with centromeres, pericentromeres, telomeres, replication origins, and R-loops.

Bacterial chromosome folding by DNA loop extrusion is here shown to rely on avoidance of SMC collisions by low SMC abundance, clustering of loading sites, efficient translocation, and rare unloading.

Ubiquitous transcriptional factor-CBP/p300 interaction induces epigenetic and transcriptional bimodality, which can be utilized to tune mean gene expression and noise independently.

A mouse model where the splicing factor SRSF1 was prevented from accumulating in the cytoplasm revealed reduced translation of thousands of mRNAs and postnatal phenotypes particularly affecting multiciliated cells.

Chromatin remodeling enzymes perform target search by utilizing ATP-binding and hydrolysis to facilitate 1D-diffusion on and rapid detachment from chromatin in living yeast.

Visualization of BRM remodelers engaging their endogenous genomic targets revealed highly transient and dynamic interactions with chromatin, which are fueled by ATP-hydrolysis.

Promoter futile cycles can explain how subtle differences in genome folding sometimes generate large difference in gene expression.