Browse our latest Chromosomes and Gene Expression articles

Mutagenizing sequences enriched with promoter motifs creates gene expression de novo, and helps to understand promoter logic, regulatory evolution, and the birth of de novo genes.

N‑terminus of MSL1 protein, involved in dosage compensation in Drosophila, is required for the interaction with non-coding roX2 RNA and the assembly of the complex on the male X chromosome.

A new genomic method called MChIP-C measures H3K4me3-associated chromatin interactions with extremely high resolution and sensitivity, detecting interactions in over 60% of functionally verified enhancer-promoter pairs.

Cell cycle arrest in response to a double-stranded break is initially maintained by the DNA damage checkpoint and later by the spindle assembly checkpoint.

Aneuploid human embryonic cells are eliminated by p53-mediated apoptosis in a gene dosage dependent manner.

Drosophila melanogastereven-skipped enhancers control transcriptional bursting by modulating frequency and amplitude, regardless of varying transcription factor inputs, even when mutated to express in embryonic regions not under selective pressure.

Genetic analyses in budding yeast coupled with biochemical assays have revealed an unexpected role for the Smc5/6 complex in cellular pathways responsible for the prevention of RNA formation in genomic DNA.

The PfMORC protein is proven to play a crucial role in chromatin structure, gene regulation and heterochromatin stability, categorizing PfMORC as a strong potential candidate for novel therapeutic interventions.