Browse our latest Chromosomes and Gene Expression articles

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    1. Chromosomes and Gene Expression

    ATAD2 mediates chromatin-bound histone chaperone turnover

    Ariadni Liakopoulou, Fayçal Boussouar ... Saadi Khochbin
    ATAD2 orchestrates histone turnover during spermatogenesis, regulating H3.3 deposition, chromatin condensation, and genome packaging to ensure proper sperm genome organization and transcriptional control.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Chromosomes: Finding a role for non-coding DNA in trypanosomes

    Markus R Schmidt
    Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.
    Version of Record
    Insight
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Short activation domains control chromatin association of transcription factors

    Vinson B Fan, Abrar A Abidi ... Max V Staller
    Single-molecule tracking of transcription factors in living cells revealed how mutations that make short activation domains stronger increased the fraction of transcription factor molecules bound to chromatin and led to longer residence times on chromatin.
    1. Chromosomes and Gene Expression

    Fragile nucleosomes are essential for RNA Polymerase II to transcribe in eukaryotes

    Lingbo Li, Samuel Hunter ... Gongyi Zhang
    Not revised
    Reviewed Preprint v1
    • Important
    • Inadequate
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

    Naphannop Sereesongsaeng, Carole Bataille ... Terence Rabbitts
    Antibody surrogate degraders of LMO2 indicate that transcription complexes are susceptible to drug discovery and are therefore druggable.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Role of ADMA-histones in dual-strand piRNA source loci recognition by Rhino

    Raku Saito, Hirotsugu Ishizu ... Mikiko C Siomi
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-throughput development and characterization of new functional nanobodies for gene regulation and epigenetic control in human cells

    Jun Wan, Abby R Thurm ... Lacramioara Bintu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression

    Decapping activators Edc3 and Scd6 act redundantly with Dhh1 in post-transcriptional repression of starvation-induced pathways

    Rakesh Kumar, Fan Zhang ... Alan G Hinnebusch
    Multi-omics analyses reveal redundant functions of yeast mRNA decapping activators Scd6 and Edc3 in facilitating recruitment of helicase Dhh1 and accelerating degradation of transcripts required for respiration in glucose-replete cells.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

    Richard C Centore, Luis MM Soares ... Steven F Bellon
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Rearrangement of 3D genome organization in breast cancer epithelial to mesenchymal transition and metastasis organotropism

    Priyojit Das, Rebeca San Martin ... Rachel Patton McCord
    Chromosome compartment analysis of a cancer cell line cohort reveals different subsets of compartment changes where some track epithelial to mesenchymal transition while others reflect secondary metastatic organ-specific reorganizations.
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