Browse our latest Chromosomes and Gene Expression articles

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    1. Developmental Biology
    2. Chromosomes and Gene Expression

    HIF1A contributes to the survival of aneuploid and mosaic pre-implantation embryos

    Estefania Sanchez-Vasquez, Marianne E Bronner, Magdalena Zernicka-Goetz
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Convincing
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance

    Maruti Nandan Rai, Qing Lan ... Koon Ho Wong
    The dynamic transcription responses of the human fungal pathogen Candida glabrata during macrophage infection is revealed and a novel transcription factor important for the responses to macrophage, proliferation within macrophage, as well as anti-fungal drug resistance has been discovered.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Molecular basis of neurodegeneration in a mouse model of Polr3-related disease

    Robyn D Moir, Emilio Merheb ... Ian M Willis
    A global reduction in tRNA differentially affects brain regions and tissues in a mouse model of Polr3-related disease leading to activation of integrated stress and innate immune responses and neurodegeneration.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

    Ting-Wen Chen, Hsiao-Wei Liao ... Chung-Te Chang
    For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

    Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Large-scale analysis of the integration of enhancer-enhancer signals by promoters

    Miguel Martinez-Ara, Federico Comoglio, Bas van Steensel
    A high-throughput enhancer-enhancer-promoter reporter assay indicates that pairs of enhancers generally activate promoters in a near-additive manner, and that promoters transform their collective effect non-linearly.
    1. Chromosomes and Gene Expression
    2. Medicine

    LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

    Xianghong Xie, Mingyue Gao ... Xiaojun Liu
    LncRNA-Snhg3 regulates lipid metabolism by affecting chromatin accessibility which indicates that lncRNA-mediated epigenetic modification has a crucial role in the pathology of metabolic dysfunction-associated fatty liver disease.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Trans regulation of an odorant binding protein by a proto-Y chromosome affects male courtship in house fly

    Pablo J Delclos, Kiran Adhikari ... Richard Meisel
    An integrative approach is used to identify a mechanism by which the fitness effects of Y chromosomes can manifest via trans effects on autosomal genes, through their effects on male courtship and other sexually selected traits.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    HIV integrase compacts viral DNA into biphasic condensates

    Pauline J Kolbeck, Marjolein de Jager ... Willem Vanderlinden
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Chromosomes and Gene Expression

    Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes

    Linda S Rubio, Suman Mohajan, David S Gross
    In response to ethanol stress, the yeast transcription factor Hsf1 forms nuclear condensates and drives the coalescence of target genes prior to their transcriptional activation while in response to thermal stress these three phenomena are tightly coordinated.
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