Browse our latest Chromosomes and Gene Expression articles

Cryogenic electron microscopy has been used to determine the detailed structure of an intermediate state called a “D-loop” that forms when strands of DNA are exchanged during homologous recombination.

YEATS2 and GCDH are upregulated in head and neck cancer in an SP1-dependent manner, leading to enhanced levels of promoter histone crotonylation which in turn elevates expression of EMT-associated SPARC.

Single-molecule mRNA and protein quantification, combined with stochastic modelling, uncover a post-transcriptional regulatory mechanism that controls the expression of the extremely low-abundance DNA double-strand break repair enzyme RecBCD.

Srs2 binding to PCNA and subsequent Mec1-dependent sumoylation regulate RPA-mediated checkpoint signaling.

Abundant single-stranded telomeric DNA distinguishes alternative lengthening of telomeres-positive cells and represents a potential biomarker and therapeutic vulnerability.

Genetic analyses of rare non-mosaic females define X-inactivation status for 380 genes and uncover widespread X-chromosome skewing in the general population, providing insights into sex-biased traits and X-linked disease expression.

Hamlet regulates heterotypic epithelial fusion by controlling spatial and temporal expression of known and novel epithelial regulators like Wnt and Tl pathway components, a mechanism potentially conserved through evolution.

Experiments with tools designed to detect DNA damage reveal unique and conserved features of telomeres in cancer cells.