Browse our latest Chromosomes and Gene Expression articles

The budding yeast transcription factors Reb1 and Cbf1 function as pioneer factors by slowly dissociating from nucleosomes, allowing them to target and unwrap nucleosomes efficiently to regulate transcription.

UPF1 associates with nascent transcripts and plays a broad role in nuclear processes of gene expression.

Cryo-EM structures of RNA polymerase I reveal considerable 'transformers-like' rearrangements where one subcomplex dissociates and is replaced by one domain of another subunit, possibly as an additional layer of transcriptional control.

A single-molecule biophysical approach reveals that the C-terminal domain of ParB blocks ParB network formation by heterodimerization with the full-length protein, which remains bound to the DNA.

Two distinct processes drive coordinated synthesis of purine and pyridine (NAD⁺) nucleotides in response to AICAR derivatives and ATP.

Common nuclear genetic variants are associated with fundamental biological processes occurring in human mitochondria and potentially point to novel roles for nuclear genes in transcriptional regulation of the mitochondrial genome.

In Caenorhabditis elegans histone methylation (H3K9me3) controls the synthesis of heritable small RNAs in a gene-specific manner and thus enables 'flagging' of newly-acquired genes.

Long noncoding RNA Norad performs an essential function in mammalian physiology by inhibiting the activity of PUMILIO RNA binding proteins, thereby suppressing a multi-system degenerative phenotype resembling premature aging.

In mice, deleting a long noncoding RNA drives premature aging.

The myogenic lineage transcription factor, MYOD1, amplifies and works with the core clock factors to support a daily muscle gene expression program.