Browse our latest Chromosomes and Gene Expression articles

In concert phosphorylation site modification of both XRCC4 and XLF C-terminal disordered tails promotes disassembly of XRCC4/XLF DNA tethers during c-NHEJ.

Oct1 replaces Oct4 at critical targets shortly after ESC differentiation to promote expression of lineage-specific genes and repress lineage-inappropriate genes.

A new paradigm of DNA methylation mediated gene activation and chromatin remodeling provides a general framework to dissect the biological functions of DNA methylation readers and effectors.

The METHYL-CpG-BINDING DOMAIN 7 (MBD7) complex promotes the activation (rather than repression) of transgenes that undergo DNA methylation and it does so without significantly altering their methylation status, placing this complex downstream of DNA methylation.

The discovery of a mechanism that causes DNA deletions during non-canonical DNA replication termination is described.

An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.

In vivo and in vitro elongation factor-RNA interaction data provide a missing link in understanding how processive elongation complexes are formed on active genes and disassembled at the end of genes.

The relative levels of histones and transcription factors in the nucleus determine transcriptional output in zebrafish embryos.

Gene regulatory elements can target a chromatin regulatory complex to a single chromosome in the genome through hierarchical specification and long distance cooperation.

Single-molecule imaging of CTCF and cohesin in live cells suggests that chromatin loops are dynamic structures that frequently form and fall apart.