The flexible stalk region of sTREM2 binds the Ig-like domain, altering stability and ligand accessibility—a biochemically testable mechanism with broad implications for (s)TREM2 biology and rational Alzheimer's disease therapeutic design.
Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani
C. elegans foraging decisions are guided by learned environmental features, integrating recent patch quality with internal satiety to balance exploration and exploitation.
A Maxwell Burroughs, Gianlucca G Nicastro, L Aravind
A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.
Ten-microsecond atomistic simulations directly capture the voltage activation of the Core-MT big potassium channel, revealing novel voltage sensing and sensor-pore coupling mechanisms that have largely eluded the community.
Lucas Fuentes Valenzuela, Paul Francois, Jan M Skotheim
Coarse-grained models of cellular growth and high-throughput empirical genetic data support the Product neutrality function in which a double-mutant fitness is the product of single-mutant fitnesses.
Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
Convolutional embedding models efficiently capture wide sequence context in antibody somatic hypermutation, avoiding exponential k-mer parameter scaling and eliminating the need for per-site modeling.
Eloise Giraud, Michael Lynn ... Jean-Philippe Thivierge
A novel software tool and ground-truth optogenetic validation is provided to automatically detect putative excitatory and inhibitory cells in neuronal recordings performed with large-scale multielectrode arrays.
Michelle Jin, Simon O Ogundare ... Christine Ann Denny
A new scalable workflow for analyzing multiple ensemble datasets incorporates SMARTTR, an R package supporting network analysis, visualization, and the import of external datasets.
