Browse our latest Computational and Systems Biology articles

Page 13 of 125
    1. Computational and Systems Biology

    Barcode-free multiplex plasmid sequencing using Bayesian analysis and nanopore sequencing

    Masaaki Uematsu, Jeremy M Baskin
    SAVEMONEY is a computational tool that guides users to mix plasmids prior to nanopore sequencing, reducing the effective cost of whole-plasmid sequencing to below that of Sanger sequencing.
    1. Computational and Systems Biology

    Unsupervised Representation Learning of C. elegans Poses and Behavior Sequences From Microscope Video Recordings

    Maurice Deserno, Katarzyna Bozek
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

    Jan Stuchly, David Novak ... Tomas Kalina
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Shinichi Kawaguchi, Xin Xu ... Toshie Kai
    AlphaFold2-based large-scale screening reveals novel protein interactions, accelerating functional studies of piRNA pathway proteins and expanding bioinformatic-experimental integration.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural population dynamics underlying evidence accumulation in multiple rat brain regions

    Brian DePasquale, Carlos D Brody, Jonathan W Pillow
    A computational framework for combining neural and behavioral data to infer latent dynamics underlying decision-making reveals distinct accumulation dynamics in different brain regions in the rat.
    1. Neuroscience
    2. Computational and Systems Biology

    Switching perspective: Comparing ground-level and bird’s-eye views for bumblebees navigating dense environments

    Annkathrin Sonntag, Odile Sauzet ... Olivier Bertrand
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Computational and Systems Biology
    2. Cancer Biology

    Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation

    Yanbin Wang, Yuqi Wu ... Yanmei Zou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

    Boris Noyvert, A Mesut Erzurumluoglu ... Zhihao Ding
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
    Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Computational and Systems Biology

    Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms

    George N Bendzunas, Dominic P Byrne ... Natarajan Kannan
    Characterization of redox-active cysteines illuminates the understudied regulatory mechanisms of brain-selective kinases.
Newer articles Older articles