Computational pipeline SPICE systematically screens and predicts novel protein-protein binding complexes including the previously unrecognized global association and functional cooperation between IKZF1 and AP1.
Rachael Kuintzle, Leah A Santat, Michael B Elowitz
The Notch signaling pathway can use its various ligands, receptors, and Fringe proteins to generate diverse intra- and intercellular signaling behaviors.
Diverse histories of viral exposure, for example in individuals of different age, makes viral evolution less predictable with features of adaptive and neutral evolution.
Human-based electromechanical simulations reveal electrocardiogram biomarkers are better indicators of pro-arrhythmic substrate after myocardial infarction than ejection fraction.
Measuring mitochondrial respiration in frozen tissue samples provides the first comprehensive atlas of how aging affects mitochondrial function in mice.
