Combining computer modeling and experiments in animals shows that the spatial organization of thymic epithelial cells affects the availability of signaling molecules that regulate thymocyte proliferation and development.
The flexible stalk region of sTREM2 binds the Ig-like domain, altering stability and ligand accessibility—a biochemically testable mechanism with broad implications for (s)TREM2 biology and rational Alzheimer's disease therapeutic design.
Jessica A Haley, Tianyi Chen ... Sreekanth H Chalasani
C. elegans foraging decisions are guided by learned environmental features, integrating recent patch quality with internal satiety to balance exploration and exploitation.
A Maxwell Burroughs, Gianlucca G Nicastro, L Aravind
A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.
Ten-microsecond atomistic simulations directly capture the voltage activation of the Core-MT big potassium channel, revealing novel voltage sensing and sensor-pore coupling mechanisms that have largely eluded the community.
Lucas Fuentes Valenzuela, Paul Francois, Jan M Skotheim
Coarse-grained models of cellular growth and high-throughput empirical genetic data support the Product neutrality function in which a double-mutant fitness is the product of single-mutant fitnesses.
Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
Convolutional embedding models efficiently capture wide sequence context in antibody somatic hypermutation, avoiding exponential k-mer parameter scaling and eliminating the need for per-site modeling.
Eloise Giraud, Michael Lynn ... Jean-Philippe Thivierge
A novel software tool and ground-truth optogenetic validation is provided to automatically detect putative excitatory and inhibitory cells in neuronal recordings performed with large-scale multielectrode arrays.
