Browse our latest Computational and Systems Biology articles

Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO₂.

High-resolution simulations of evolving microbial populations reveal that microscopic epistasis slows the rate of adaptation, while clonal interference can either speed it up or leave it fixed.

The transition from a restrictive patterning mechanism to one sensitive to a variety of environmental cues in NOTCH-mediated angiogenesis offers crucial insights into vascularization in damaged organs and cancer therapy.

A mammalian protein with RNA recognition motifs can be used in bacteria to engineer post-transcriptional regulation.

Combining biophysically realistic hippocampal neurons with coupled phase oscillators that represent theta inputs enables probing the phase-dependent effects of neurostimulation on theta-nested gamma oscillations in normal and pathological states.

A new study reveals structural details of the bacterial essential interactome, opening new avenues for antibiotic discovery.

A computer model predicts different mechanisms of blood pressure regulation and effective hypertensive therapy for males and females, thereby serving as a foundational tool for improved treatment precision.

Genetic background and dietary environment interact to reshape metabolic signalling networks, and the resulting signalling diversity can illuminate regulatory mechanisms of complex traits.

KinCytE is a web-based platform that explores kinase-cytokine-driven signaling and its relevance to understanding and treating diseases linked to disruptions in these pathways.

The PrEDiCT scheme infers disease-affected cell types from the expression of disease-associated genes in single-cell expression atlases, thereby providing cellular context and enhancing mechanistic understanding for 328 Mendelian diseases.