Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Neuroscience

    Motor biases reflect a misalignment between visual and proprioceptive reference frames

    Tianhe Wang, J Ryan Morehead ... Jonathan S Tsay
    The pattern of reaching biases is stable across contexts and can be attributed to a misalignment between eye-centric and body-centric representations of position.
    1. Computational and Systems Biology

    Ribosome demand links transcriptional bursts to protein expression noise

    Sampriti Pal, Upasana Ray, Riddhiman Dhar
    Propagation of expression noise from mRNA to protein level is influenced by variation in availability of ribosomal machinery.
    1. Computational and Systems Biology
    2. Neuroscience

    Linking spinal circuit reorganization to recovery after thoracic spinal cord injury

    Natalia A Shevtsova, Andrew B Lockhart ... Simon M Danner
    A computational model mechanistically links spinal circuit reorganization to recovered locomotion after incomplete spinal cord injury.
    1. Computational and Systems Biology
    2. Neuroscience

    Deep neural networks to register and annotate cells in moving and deforming nervous systems

    Adam A Atanas, Alicia Kun-Yang Lu ... Steven W Flavell
    New machine vision tools are used to align densely packed cells recorded from live, deforming tissues and automatically annotate the identities of the recorded cell types.
    1. Computational and Systems Biology
    2. Cancer Biology

    End-to-end proteogenomics for discovery of cryptic and non-canonical cancer proteoforms using long-read transcriptomics and multi-dimensional proteomics

    Katarzyna Kulej, Asher Preska Steinberg ... Alex Kentsis
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Gait transition mechanism from quadrupedal to bipedal locomotion in the Japanese macaque based on inverted pendulum

    Koki Nishizaki, Mau Adachi ... Shinya Aoi
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cancer Biology
    2. Computational and Systems Biology

    Single-cell atlas of AML reveals age-related gene regulatory networks in t(8;21) AML

    Jessica Whittle, Stefan Meyer ... Mudassar Iqbal
    A comprehensive single-cell atlas of AML uncovers regulatory networks and age-dependent molecular differences to advance the understanding of disease mechanisms and enable subtype-specific therapeutic strategies.
    1. Neuroscience
    2. Computational and Systems Biology

    Individual differences drive social hierarchies in mouse societies

    Jonathan R Reinwald, Sarah Ghanayem ... Wolfgang Kelsch
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    Leveraging Disease Association Degree for High-Accuracy MicroRNA Target Prediction

    Baiming Chen
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Unraveling the Molecular Mechanisms of ABHD5 Membrane Targeting

    Amit Kumar, Matthew Sanders ... Yu-ming M Huang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
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