Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology

    Generative modeling for RNA splicing predictions and design

    Di Wu, Natalie Maus ... Yoseph Barash
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    A mathematical model that predicts human biological age from physiological traits identifies environmental and genetic factors that influence aging

    Sergiy Libert, Alex Chekholko, Cynthia Kenyon
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Thrifty wide-context models of B cell receptor somatic hypermutation

    Kevin Sung, Mackenzie M Johnson ... Frederick A Matsen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology

    Untargeted pixel-by-pixel metabolite ratio imaging as a novel tool for biomedical discovery in mass spectrometry imaging

    Huiyong Cheng, Dawson Miller ... Qiuying Chen
    A novel R ratiometric imaging tool provides enhanced knowledge obtained from conventional spatial data profiling technologies.
    1. Computational and Systems Biology

    Passive shaping of intra- and intercellular m6A dynamics via mRNA metabolism

    David Dierks, Ran Shachar ... Schraga Schwartz
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning

    Ruihan Dong, Rongrong Liu ... Cheng Zhu
    Peptides designed by artificial intelligence restrict both drug-resistant bacteria and rapidly evolving viruses.
    1. Computational and Systems Biology
    2. Neuroscience

    A statistical framework for analysis of trial-level temporal dynamics in fiber photometry experiments

    Gabriel Loewinger, Erjia Cui ... Francisco Pereira
    A fiber photometry analysis framework based on functional mixed models enhances the detection of effects by testing signal-variable associations at each trial timepoint and accounting for between-animal heterogeneity.
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Celldetective: an AI-enhanced image analysis tool for unraveling dynamic cell interactions

    Rémy Torro, Beatriz Díaz-Bello ... Laurent Limozin
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Computational and Systems Biology

    Efficient coding in biophysically realistic excitatory-inhibitory spiking networks

    Veronika Koren, Simone Blanco Malerba ... Stefano Panzeri
    Recurrent spiking networks that process input stimuli with optimal efficiency have key emerging properties that are similar to those of biological neural networks.
    1. Computational and Systems Biology

    Raw signal segmentation for estimating RNA modification from Nanopore direct RNA sequencing data

    Guangzhao Cheng, Aki Vehtari, Lu Cheng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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