Browse our latest Computational and Systems Biology articles

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    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    DNA O-MAP uncovers the molecular neighborhoods associated with specific genomic loci

    Yuzhen Liu, Christopher D McGann ... Devin K Schweppe
    DNA O-MAP enables proximity labeling at specific genomic loci in fixed cells using programmable oligonucleotides, revealing locus-proximal proteomes and chromatin interactions without genetic modification.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Investigating the native functions of [NiFe]-CODH through genomic context analysis

    Maximilian Böhm, Henrik Land
    Genomic neighborhood signatures delineate catalytic versus putative regulatory CODH clades, establishing a framework for predicting enzyme functionality and guiding discovery of biocatalysts for CO2 reduction.
    1. Neuroscience
    2. Computational and Systems Biology

    Opening the black box: a modular approach to spike sorting

    Samuel Garcia, Chris Halcrow ... Pierre Yger
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology

    A real-time, multi-animal model for automatic face detection and identification of freely moving common marmosets based on YOLOv8 algorithms

    Jiayue Yang, James Wang, Justine Cléry
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Out-of-balance Growth Enables Cost-free Synthesis of the Flagellum and Other Proteins in a Single Bacterium

    Mayra Garcia-Alcala, Josiah C Kratz, Philippe Cluzel
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Neuroscience

    Visual information is broadcast among cortical areas in discrete channels

    Yiyi Yu, Jeffery N Stirman ... Spencer LaVere Smith
    Activity fluctuations, or noise correlations, are robust measures of neuronal connectivity and they reveal that neural circuity controls mixing of information at a granular level across millimeter-length scales.
    1. Computational and Systems Biology

    Anatomical basis of sex differences in the electrocardiogram identified by three-dimensional torso-heart imaging reconstruction pipeline

    Hannah J Smith, Blanca Rodriguez ... Abhirup Banerjee
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    • Incomplete
    1. Computational and Systems Biology
    2. Medicine

    Global molecular landscape of early MASLD progression in human obesity

    Qing Zhao, William De Nardo ... Philipp Kaldis
    GTPases could be drivers of liver fibrosis in MASLD and potential future therapeutic targets.
    1. Computational and Systems Biology
    2. Cancer Biology

    Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

    Anthony Hart, Sung-Young Shin, Lan K Nguyen
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Neuroscience
    2. Computational and Systems Biology

    Policy-Gradient Reinforcement Learning as a General Theory of Practice-Based Motor Skill Learning

    Adrian M Haith
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
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