Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Neuroscience

    Morphogenesis and morphometry of brain folding patterns across species

    Sifan Yin, Chunzi Liu ... L Mahadevan
    The morphogenesis of brain folding patterns across species is studied by physical gel models, simulations, and a quantitative morphometric analysis.
    1. Computational and Systems Biology
    2. Neuroscience

    Predictive modeling of hematoma expansion from non-contrast computed tomography in spontaneous intracerebral hemorrhage patients

    Natasha Ironside, Kareem El Naamani ... VISTA-ICH
    In spontaneous intracerebral hemorrhage patients, features of hematoma expansion can be visualized and predicted from non-contrast computed tomography using transport-based morphometry.
    1. Computational and Systems Biology
    2. Neuroscience

    Human EEG and artificial neural networks reveal disentangled representations and processing timelines of object real-world size and depth in natural images

    Zitong Lu, Julie Golomb
    Neural and computational evidence reveals that real-world size is a temporally late, semantically grounded, and hierarchically stable dimension of object representation in both human brains and artificial neural networks.
    1. Computational and Systems Biology

    A network regularized linear model to infer spatial expression pattern for single cell

    Chaohao Gu, Hu Chen, Zhandong Liu
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Convincing
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Exploiting fluctuations in gene expression to detect causal interactions between genes

    Euan Joly-Smith, Mir Mikdad Talpur ... Andreas Hilfinger
    Analyzing stochastic cell-to-cell variability can potentially reveal causal interactions in gene regulatory networks.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Evolutionary remodeling of non-canonical ORF translation in mammals

    Yue Chang, Tianyu Lei ... Hong Zhang
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Neuroscience

    The electrogenicity of the Na+/K+-ATPase poses challenges for computation in highly active spiking cells

    Liz Weerdmeester, Jan-Hendrik Schleimer, Susanne Schreiber
    The electrogenic Na+/K+-ATPase generates a slow activity-dependent feedback signal that influences the computation of excitable cells and requires additional compensatory mechanisms during periods of high sustained activity.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoNet 2.0: An innovative approach for qualitative assessment and segmentation curation of large-scale 3D time-lapse imaging datasets

    Benjamin Gallean, Tao Laurent ... Emmanuel Faure
    A collaborative open-source platform enabling interactive 3D visualization, quantitative evaluation, and expert curation of complex biological morphologies to enhance the quality and reproducibility of large-scale imaging studies.
    1. Computational and Systems Biology

    TSvelo: Comprehensive RNA velocity by modeling the cascade of gene regulation, transcription and splicing

    Jiachen Li, Zhe Wang ... Ye Yuan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    Learning sequence-function relationships with scalable, interpretable Gaussian processes

    Juannan Zhou, Carlos Martí-Gómez ... David M McCandlish
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
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