Browse our latest Computational and Systems Biology articles

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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    In silico screening by AlphaFold2 program revealed the potential binding partners of nuage-localizing proteins and piRNA-related proteins

    Shinichi Kawaguchi, Xin Xu ... Toshie Kai
    AlphaFold2-based large-scale screening reveals novel protein interactions, accelerating functional studies of piRNA pathway proteins and expanding bioinformatic-experimental integration.
    1. Computational and Systems Biology
    2. Neuroscience

    Neural population dynamics underlying evidence accumulation in multiple rat brain regions

    Brian DePasquale, Carlos D Brody, Jonathan W Pillow
    A computational framework for combining neural and behavioral data to infer latent dynamics underlying decision-making reveals distinct accumulation dynamics in different brain regions in the rat.
    1. Neuroscience
    2. Computational and Systems Biology

    Switching perspective: Comparing ground-level and bird’s-eye views for bumblebees navigating dense environments

    Annkathrin Sonntag, Odile Sauzet ... Olivier Bertrand
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry

    Yixuan Chen, Guoye Guan ... Chao Tang
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Computational and Systems Biology
    2. Cancer Biology

    Decoding Liver Cancer Prognosis: From Multi-omics Subtypes, Prognostic Models to Single Cell Validation

    Yanbin Wang, Yuqi Wu ... Yanmei Zou
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Imputation of structural variants using a multi-ancestry long-read sequencing panel enables identification of disease associations

    Boris Noyvert, A Mesut Erzurumluoglu ... Zhihao Ding
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

    A Sofia F Oliveira, Fiona L Kearns ... Adrian J Mulholland
    Equilibrium and nonequilibrium simulations uncover how the fatty acid site in the SARS-CoV-2 spike modulates protein dynamics, revealing its intricate allosteric connections and the impact of glycans on these networks.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Predictive modeling of hematoma expansion from non-contrast computed tomography in spontaneous intracerebral hemorrhage patients

    Natasha Ironside, Kareem El Naamani ... ERICH Investigators and the VISTA-ICH collaboration
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology

    A network regularized linear model to infer spatial expression pattern for single cell

    Chaohao Gu, Hu Chen, Zhandong Liu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Computational and Systems Biology

    Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms

    George N Bendzunas, Dominic P Byrne ... Natarajan Kannan
    Characterization of redox-active cysteines illuminates the understudied regulatory mechanisms of brain-selective kinases.
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