Browse our latest Computational and Systems Biology articles

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    1. Epidemiology and Global Health
    2. Computational and Systems Biology

    Refining uncertainty about the TAK-003 dengue vaccine with a multi-level model of clinical efficacy trial data

    Manar Alkuzweny, Guido España, T Alex Perkins
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Comparing the outputs of intramural and extramural grants funded by National Institutes of Health

    Xiang Zheng, Qiyao Yang ... B Ian Hutchins
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework

    William JF Rieger, Mikael Boden ... Ariane Mora
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation
    2. Computational and Systems Biology

    Clonal stochasticity in early NK cell response to mouse cytomegalovirus is generated by mature subsets of varying proliferative ability

    Darren Wethington, Saeed Ahmad ... Jayajit Das
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Computational and Systems Biology

    Lipid packing contributes to the confinement of caveolae to the plasma membrane

    Elin Larsson, Aleksei Kabedev ... Richard Lundmark
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Cell type-specific network analysis in Diversity Outbred mice identifies genes potentially responsible for human bone mineral density GWAS associations

    Luke J Dillard, Gina M Calabrese ... Charles R Farber
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Compelling
    • Solid
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Importance of higher-order epistasis in protein sequence-function relationships

    Palash Sethi, Juannan Zhou
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology

    Regulation of Transcriptional Bursting and Spatial Patterning in Early Drosophila Embryo Development

    César Nieto, Zahra Vahdat ... Abhyudai Singh
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Macroscopic Analyses of RNA-Seq Data to Reveal Chromatin Modifications in Aging and Disease

    Achal Mahajan, Francesca Ratti ... Vishrawas Gopalakrishnan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Neuroscience

    Neural dynamics of reversal learning in the prefrontal cortex and recurrent neural networks

    Christopher M Kim, Carson C Chow, Bruno B Averbeck
    Neural activity during reversal learning encodes decision-related evidence integrated across trials and shows substantial dynamics during each trial, suggesting an extension of the line attractor model that incorporates non-stationary dynamics.
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