Browse our latest Computational and Systems Biology articles

Page 7 of 130
    1. Computational and Systems Biology

    Dynamic architecture of mycobacterial outer membranes revealed by all-atom simulations

    Turner P Brown, Matthieu Chavent, Wonpil Im
    The first all-atom models of the mycobacterial outer membrane reveal how lipid organization and asymmetry generate a structurally heterogeneous barrier that underlies its unique permeability properties.
    1. Cell Biology
    2. Computational and Systems Biology

    Geometry shapes cytoplasmic Cdk1 waves that drive cortical dynamics

    Daniel Cebrián-Lacasa, Marcin Leda ... Lendert Gelens
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Real-time transcriptomic profiling in distinct experimental conditions

    Tamer Butto, Stefan Pastore ... Susanne Gerber
    Real-time nanopore transcriptomics enables early detection of expression changes and sample quality, offering a rapid, cost-effective strategy for experimental quality control and transcriptomic analysis.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling

    Caleb Hallinan, Hyun Joo Ji ... Jean Fan
    Computational assessment identifies probe binding errors in a widely used commercial platform for spatial transcriptomics.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Neuroscience
    2. Computational and Systems Biology

    Parallel Wires: A Conserved Principle of Contralateral-Ipsilateral Segregation in the Visual Corpus Callosum

    Jiaowen Wang, Yanming Wang ... Xiaoxiao Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Computational and Systems Biology

    Single-mRNA imaging and modeling reveal coupled translation initiation and elongation rates

    Irene Lamberti, Jeffrey A Chao ... Felix Naef
    Mammalian cells dynamically scale translation initiation to match distinct elongation rates, preventing ribosome crowding and preserving protein synthesis homeostasis across diverse transcripts.
    1. Neuroscience
    2. Computational and Systems Biology

    Long-range neural pathways for octopus chemotactile processing revealed from periphery-to-brain by centimeter-field microCT

    Andrew Sugarman, Daniel Vanselow ... Keith C Cheng
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Identification and comparison of orthologous cell types from primate embryoid bodies shows limits of marker gene transferability

    Jessica Jocher, Philipp Janssen ... Ines Hellmann
    Analysis of scRNA-seq data from primate embryoid bodies highlights the value of cross-species comparisons for identifying and characterizing cell types, as marker genes can evolve fast.