Browse our latest Computational and Systems Biology articles

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    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of adapting pathogens and host immunity

    Pierre Barrat-Charlaix, Richard A. Neher
    1. Computational and Systems Biology

    Perturbation-response analysis of in silico metabolic dynamics in nonlinear regime: Hard-coded responsiveness in the cofactors and network sparsity

    Yusuke Himeoka, Chikara Furusawa
    1. Computational and Systems Biology

    Accurate prediction of CDR-H3 loop structures of antibodies with deep learning

    Hedi Chen, Xiaoyu Fan ... Boxue Tian
    A deep learning-based toolkit predicting the 3D structures of monoclonal antibodies and nanobodies outperforms other current computational methods.
    1. Computational and Systems Biology

    Semantical and Geometrical Protein Encoding Toward Enhanced Bioactivity and Thermostability

    Yang Tan, Bingxin Zhou ... Liang Hong
    1. Medicine
    2. Computational and Systems Biology

    Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning

    Gitanjali Roy, Rameesha Syed ... Michael A. Kalwat
    1. Computational and Systems Biology
    2. Medicine

    The vaginal immunoproteome for the prediction of spontaneous preterm birth: A retrospective longitudinal study

    Zachary Shaffer, Roberto Romero ... Nardhy Gomez-Lopez
    The vaginal immunoproteome in pregnancy is more predictive of spontaneous preterm birth (sPTB) than maternal characteristics alone, with sPTB cases showing heightened pro-inflammatory profiles accompanied by reduced levels of antimicrobial proteins/peptides.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Benchmarking tRNA-Seq quantification approaches by realistic tRNA-Seq data simulation identifies two novel approaches with higher accuracy

    Tom Smith, Mie Monti ... Lajos Kalmár
    1. Computational and Systems Biology

    Balancing reaction-diffusion network for cell polarization pattern with stability and asymmetry

    Yixuan Chen, Guoye Guan ... Chao Tang
    1. Computational and Systems Biology

    Protein Kinases: Redox takes control

    Iván Plaza-Menacho
    A study of two enzymes in the brain reveals new insights into how redox reactions regulate the activity of protein kinases.
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    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers

    Javier I Ottaviani, Virag Sagi-Kiss ... Gunter GC Kuhnle
    The reliance on food composition databases for the assessment of dietary intake is unreliable and results in a large bias when investigating the associations between diet and disease risk.
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