Browse our latest Computational and Systems Biology articles

Killing their neighbors allows bacteria to steal genes, including antibiotic resistance genes, which we observed under a microscope, quantified, modeled, and predicted potentially guiding strategies to combat it.

Bacteria can overcome environmental challenges by killing nearby bacteria and incorporating their DNA.

Correlating changes in structure and gene expression in cone photoreceptors of mice daily, between birth and eye opening, created a resource that supports research in photoreceptor function, development, transplantation and repair.

CDK9 inhibition in human cells uncovers that Pol II pause duration regulates the frequency of productive transcription initiation.

A combination of transcriptomics, proteomics and modelling identifies a network of interacting protein phosphatases that act as a biological switch to move cells from the stem cell compartment to the differentiated compartment in cultured human epidermis.

Crawling Drosophila larvae and C. elegans exhibit diffusive behavior alongside directed motion, and the dynamics of this navigation can be analyzed with techniques developed in understanding protein folding, using a Markov state model.

Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.

State-of-the-art computational methods have facilitated the construction of plant-based sentinels for detecting toxic molecules in the environment.

Project Rephetio combines data integration and systematic analysis to enable drug repurposing predictions on an unprecedented scale.

Sexual arousal, exposure to aphrodisiac pheromones, or mere activation of peripheral pheromone-sensing neurons can modulate sleep homeostasis and are able to counteract the effects of sleep deprivation in Drosophila.