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    1. Developmental Biology
    2. Neuroscience

    Axon Guidance: Watching axons on the move

    Maria I Lazaro-Pena, Carlos A Diaz-Balzac
    The ligand Netrin mediates axon guidance through a combination of haptotaxis over short distances and chemotaxis over longer distances.
    Version of Record
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    1. Developmental Biology

    Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish

    Wenqing Li, Sara McCurdy ... Mark H Ginsberg
    The β1 adrenergic receptor is a key regulator of cerebral cavernous malformation pathogenesis.
    1. Developmental Biology

    Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis

    Igor Kondrychyn, Liqun He ... Li-Kun Phng
    Investigation of Aquaporin water channels unveils water inflow and build-up of hydrostatic pressure in endothelial tip cells as a novel mechanism of endothelial cell migration and blood vessel formation.
    1. Developmental Biology

    Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish

    Oguzhan F Baltaci, Andrea Usseglio Gaudi ... Benjamin M Hogan
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    SMARCAD1 and TOPBP1 contribute to heterochromatin maintenance at the transition from the 2C-like to the pluripotent state

    Ruben Sebastian-Perez, Shoma Nakagawa ... Maria Pia Cosma
    The chromatin-bound proteome of embryonic stem cells transitioning to 2C-like cells uncovers chromatin regulators involved in heterochromatin formation.
    1. Developmental Biology

    A wave of minor de novo DNA methylation initiates in mouse 8-cell embryos and co-regulates imprinted X- chromosome inactivation with H3K27me3

    Yuan Yue, Wei Fu ... Lei An
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Developmental Biology

    Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

    Yunfei Mu, Shijia Hu ... Hongjun Shi
    A ligand independent mechanical sensitive mTORC2-PKC pathway activates Notch in the endocardium of the valve forming area.
    1. Developmental Biology
    2. Neuroscience

    Volumetric trans-scale imaging of massive quantity of heterogeneous cell populations in centimeter-wide tissue and embryo

    Taro Ichimura, Taishi Kakizuka ... Takeharu Nagai
    Volumetric trans-scale imaging with a subcellular resolution across a wide field-of-view of 1.5 × 1.0 cm2 has been realized, facilitating the analysis of cellular dynamics during embryogenesis and brain function.
    1. Developmental Biology
    2. Evolutionary Biology

    Single-cell sequencing provides clues about the developmental genetic basis of evolutionary adaptations in syngnathid fishes

    Hope M Healey, Hayden B Penn ... William A Cresko
    The production of a single-cell atlas for developing syngnathid fish permits study of their unique traits.
    1. Developmental Biology
    2. Genetics and Genomics

    Genome-wide analysis of Smad and Schnurri transcription factors in C. elegans demonstrates widespread interaction and a function in collagen secretion

    Mehul Vora, Jonathan Dietz ... Cathy Savage-Dunn
    Smad and Schnurri transcription factors engage in context-dependent interactions as well as independent genomic activities, leading to regulation of collagen secretion to mediate body size regulation in C. elegans.
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