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    1. Developmental Biology
    2. Evolutionary Biology

    Insect metamorphosis is regulated differently between sexes by members of a microRNA cluster

    Chade Li, Ki Kei Chan ... Jerome HL Hui
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Developmental Biology

    Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

    Akiko Hozumi, Nozomu M Totsuka ... Yasunori Sasakura
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology
    2. Neuroscience

    Adverse impact of female reproductive signaling on age-dependent neurodegeneration after mild head trauma in Drosophila

    Changtian Ye, Ryan Ho ... James Q Zheng
    A head concussion model in fruit flies reveals that early-life exposure to mild concussions significantly increases the risk of late-life neurodegeneration, with females especially vulnerable due to reproductive factors.
    1. Developmental Biology
    2. Genetics and Genomics

    The role of heterochronic gene expression and regulatory architecture in early developmental divergence

    Nathan D Harry, Christina Zakas
    Changes in the amount and timing of gene expression during early development contribute to evolutionary divergence and life-history changes, even within a species.
    1. Developmental Biology

    Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

    Haruna Gekko, Ruri Nomura ... Takuya Wakai
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Cell Biology
    2. Developmental Biology

    H2A.Z deposition at meiotic prophase I underlies homologous recombination and pachytene genome activation during male meiosis

    Shenfei Sun, Yamei Jiang ... Xinhua Lin
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    sisterless A is required for activation of Sex lethal in the Drosophila germline

    Raghav Goyal, Ellen Baxter, Mark Van Doren
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Cell Biology
    2. Developmental Biology

    Fertilization: Switching on lysosomes

    Deepak Adhikari, John Carroll
    The formation of large endolysosomal structures in unfertilized eggs ensures that lysosomes remain dormant before fertilization, and then shift into clean-up mode after the egg-to-embryo transition.
    Version of Record
    Insight
    1. Developmental Biology

    FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

    Yuki Kaneda, Haruhiko Miyata ... Masahito Ikawa
    FBXO24, a testis-enriched E3 ubiquitin ligase, is essential for sperm flagellum formation and male fertility in mice.
    1. Cell Biology
    2. Developmental Biology

    Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity

    Filip Knop, Apolena Zounarová ... Marie Macůrková
    The SEL-5/AAK1 kinase unexpectedly influences Wnt signalling-dependent processes in a multicellular organism without using its enzymatic activity.
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