Volumetric trans-scale imaging with a subcellular resolution across a wide field-of-view of 1.5 × 1.0 cm2 has been realized, facilitating the analysis of cellular dynamics during embryogenesis and brain function.
Smad and Schnurri transcription factors engage in context-dependent interactions as well as independent genomic activities, leading to regulation of collagen secretion to mediate body size regulation in C. elegans.
The articles in this special issue highlight the diversity and complexity of research into reproductive health, including the need for a better understanding of the fundamental biology of reproduction and for new treatments for a range of reproductive disorders.
Tgfbr1 signaling governs all processes associated with the trunk to tail transition, including the repositioning of neuro-mesodermal progenitors, as well as the remodeling of the lateral plate mesoderm and embryonic endoderm.
Odessa R Yabut, Jessica Arela ... Samuel J Pleasure
Mice with Suppressor of Fused mutations have aberrant cerebellar granule cell proliferation accompanied by ectopic expression of an FGF ligand, also expressed in infantile medulloblastoma patients.
Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
