Browse our latest Developmental Biology articles

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    1. Developmental Biology

    A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate

    Eric R Brooks, Andrew R Moorman ... Jennifer A Zallen
    Single-cell RNA sequencing and computational analysis define a spatial and temporal map of gene expression during early patterning and morphogenesis of the mouse cranial neural plate, providing a resource for elucidating the transcriptional basis of mammalian brain development.
    1. Developmental Biology

    Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation

    Mehmet Mahsum Kaplan, Erika Hudacova ... Ondrej Machon
    Meis2 transcription factor instructs the mesenchyme to initiate whisker formation in the epithelium.
    1. Developmental Biology

    A-to-I RNA editing of CYP18A1 mediates transgenerational wing dimorphism in aphids

    Bin Zhu, Rui Wei ... Pei Liang
    Binding of miR-3036-5p to CYP18A1 can be prevented by an A-to-I RNA editing, thus elevating CYP18A1 expression, decreasing 20E titer, and finally regulating the wing dimorphism of offspring in aphid.
    1. Developmental Biology

    Neuroprotective role of Hippo signaling by microtubule stability control in Caenorhabditis elegans

    Hanee Lee, Junsu Kang ... Junho Lee
    The Hippo pathway maintains the integrity of differentiated neurons by modulating microtubule stability, and reducing microtubule stability of fully developed neurons offers a potential strategy to delay neuronal aging.
    1. Developmental Biology

    MMP21 behaves as a fluid flow transported morphogen to impart laterality during development

    Tim Ott, Amelie Brugger ... Axel Schweickert
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Developmental Biology

    Knockout of cyclin-dependent kinases 8 and 19 leads to depletion of cyclin C and suppresses spermatogenesis and male fertility in mice

    Alexandra V Bruter, Ekaterina A Varlamova ... Victor V Tatarskiy
    Knockout of CDK8/19, but not its inhibition, impairs spermatogenesis by reducing steroid production in Leydig cells.
    1. Developmental Biology

    A systematic review and embryological perspective of pluripotent stem cell-derived autonomic postganglionic neuron differentiation for human disease modeling

    Thomas A Bos, Elizaveta Polyakova ... Monique RM Jongbloed
    Although methods to efficiently generate functional autonomic postganglionic neurons from human pluripotent stem cells largely mirror signaling cues during embryonic development, several in vivo signaling cues remain to be explored in vitro.
    1. Cell Biology
    2. Developmental Biology

    Lens Development: Bringing signaling complexity into focus

    Sarah Y Coomson, Salil A Lachke
    A study in mice reveals key interactions between proteins involved in fibroblast growth factor signaling and how they contribute to distinct stages of eye lens development.
    Version of Record
    Insight
    1. Developmental Biology

    3D reconstruction of neuronal allometry and neuromuscular projections in asexual planarians using expansion tiling light sheet microscopy

    Jing Lu, Hao Xu ... Kai Lei
    A high-resolution, high-speed tissue imaging analysis reveals how neural and muscular tissues coordinate during planarian growth and regeneration.
    1. Developmental Biology
    2. Genetics and Genomics

    Deficiency in DNAH12 causes male infertility by impairing DNAH1 and DNALI1 recruitment in humans and mice

    Menglei Yang, Hafiz Muhammad Jafar Hussain ... Baolu Shi
    DNAH12 is essential for sperm flagellar development and male fertility in both humans and mice by interacting with dynein proteins DNAH1 and DNALI1.