Browse our latest Developmental Biology articles

Page 22 of 211
    1. Cell Biology
    2. Developmental Biology

    Formation of multinucleated osteoclasts depends on an oxidized species of cell surface-associated La protein

    Evgenia Leikina, Jarred M Whitlock ... Leonid Chernomordik
    Molecular and biochemical approaches in primary human cells illustrate how a nuclear RNA-binding protein is shifted to the surface of osteoclasts – setting their size and biological activity.
    1. Developmental Biology

    Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification

    Adiyant Lamba, Meng Zhu ... Magdalena Zernicka-Goetz
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Developmental Biology
    2. Physics of Living Systems

    Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair

    Jake Turley, Isaac V Chenchiah ... Helen Weavers
    Deep Learning Artificial Intelligence tools can be developed to accurately identify cell divisions during development and wound repair of epithelial tissue.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline

    Leif Benner, Savannah Muron ... Brian Oliver
    Many well-studied maternal developmental pathways that are required for embryonic development in Drosophila are regulated by the transcription factor OVO in the Drosophila female germline.
    1. Developmental Biology

    Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

    Saira Amir, Olatunbosun Arowolo ... Alexander Suvorov
    For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.
    1. Developmental Biology

    TMC7 deficiency causes acrosome biogenesis defects and male infertility in mice

    Jing Wang, Yingying Yin ... Zhaojian Liu
    Experiments on mice show that TMC7, a transmembrane channel-like protein, localizes to the cis-Golgi region in spermatids and that this is essential for acrosome biogenesis and male fertility.
    1. Developmental Biology

    Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

    Shuo Chen, Jie Yin ... Peidong Han
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    Embryonic origins of forebrain oligodendrocytes revisited by combinatorial genetic fate mapping

    Yuqi Cai, Zhirong Zhao ... Miao He
    Novel genetic fate-mapping strategies enabled re-analysis of cortical oligodendrocytes derived from dorsal pallium, LGE/CGE, and MGE/POA, challenging the canonical view of substantial LGE/CGE contributions and the elimination of MGE/POA-derived populations.
    Version of Record
    Short Report
    • Valuable
    • Convincing
    1. Developmental Biology
    2. Neuroscience

    Lateral/caudal ganglionic eminence makes limited contribution to cortical oligodendrocytes

    Jialin Li, Feihong Yang ... Zhuangzhi Zhang
    The contribution of the lateral/caudal ganglionic eminence to the pool of cortical oligodendrocyte precursor cells is minimal.
    Version of Record
    Short Report
    • Valuable
    • Solid
    1. Developmental Biology

    SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development

    Rula Sha, Ruochen Guo ... Ying Feng
    Genetic mouse models combined with single-cell RNA sequencing reveal the essential role of SRSF2 in directing MyoD progenitors to distinct skeletal muscle domains and controlling their differentiation through the regulation of targeted genes and alternative splicing during skeletal muscle development.