Browse our latest Developmental Biology articles

Page 30 of 216
    1. Developmental Biology
    2. Neuroscience

    Multiple guidance mechanisms control axon growth to generate precise T-shaped bifurcation during dorsal funiculus development in the spinal cord

    Bridget M Curran, Kelsey R Nickerson ... Le Ma
    Formation of dorsal axonal tracts in the spinal cord depends on multiple guidance mechanisms that control growth direction of bifurcating axons in the dorsal root entry zone.
    1. Developmental Biology
    2. Neuroscience

    Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

    Agnik Dasgupta, Caleb C Reagor ... AJ Hudspeth
    Semaphorin7A sculpts the collective arbor architecture of the lateral line nerve and facilitates neural contacts with the hair cells for synaptogenesis during neuromast development in the zebrafish.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The transcriptional landscape underlying larval development and metamorphosis in the Malabar grouper (Epinephelus malabaricus)

    Roger Huerlimann, Natacha Roux ... Timothy Ravasi
    Transcriptomic analyses of Malabar grouper show pathways known to be involved in metamorphosis are also upregulated at an early stage of larval development, suggesting an additional function during early development.
    1. Developmental Biology
    2. Neuroscience

    A unique multi-synaptic mechanism involving acetylcholine and GABA regulates dopamine release in the nucleus accumbens through early adolescence in male rats

    Melody C Iacino, Taylor A Stowe ... Mark J Ferris
    A circuit within the nucleus accumbens that exists during a specific developmental window through early adolescence male rats may serve as a substrate that underlies heightened reward seeking in this population.
    1. Developmental Biology
    2. Medicine

    SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

    Stephen E Flaherty III, Olivier Bezy ... Zhidan Wu
    Investigation of mouse models from forward mutagenetic screen reveals that the gene Spag7 is essential for embryonic development and energy homeostasis later in life.
    1. Developmental Biology
    2. Neuroscience

    Spatiotemporal changes in Netrin/Dscam1 signaling dictate axonal projection direction in Drosophila small ventral lateral clock neurons

    Jingjing Liu, Yuedong Wang ... Yao Tian
    Dynamic local microenvironments in Drosophila facilitate axonal projection direction transitions in the absence of clear landmarks.
    1. Developmental Biology

    Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation

    Yifan Wu, Kunhua Qin ... Pei Wang
    Loss of YAP1/TAZ expression in the pancreatic endocrine compartment is not a passive consequence of endocrine specification, rather, Hippo pathway-mediated inhibition of YAP1/TAZ in endocrine progenitors is a prerequisite for endocrine specification and differentiation.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Temporally resolved early bone morphogenetic protein-driven transcriptional cascade during human amnion specification

    Nikola Sekulovski, Jenna C Wettstein ... Kenichiro Taniguchi
    Analyses of transcriptomic dynamics in a new model of human amnion formation identify five continuous amniogenic transcriptional phases as well as a critical role of TFAP2A in amnion fate progression.
    1. Developmental Biology

    Drosophila medulla neuroblast termination via apoptosis, differentiation, and gliogenic switch is scheduled by the depletion of the neuroepithelial stem cell pool

    Phuong-Khanh Nguyen, Louise Y Cheng
    The termination of medulla neuroblasts is specified by the depletion of the neuroepithelium and mediated by apoptosis, differentiation, and gliogenic switch.
    1. Developmental Biology
    2. Neuroscience

    Energetic demands regulate sleep-wake rhythm circuit development

    Amy R Poe, Lucy Zhu ... Matthew S Kayser
    Behavioral and circuit analyses show that changes to energetic demand are a key driver of consolidation of daily sleep and feeding patterns as animals mature.