Browse our latest Developmental Biology articles

Page 48 of 209
    1. Developmental Biology

    Molecular characterization of the intact mouse muscle spindle using a multi-omics approach

    Bavat Bornstein, Lia Heinemann-Yerushalmi ... Elazar Zelzer
    Transcriptomic and proteomic analyses of the murine intact muscle spindle provide comprehensive datasets of its different tissues and identify new tools to study its development and function.
    1. Developmental Biology

    A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

    Kavitha Chinnaiya, Sarah Burbridge ... Marysia Placzek
    Fate-mapping, combined with gain- and loss-of-function approaches, reveal the role of BMP signalling in the spatio-temporal development of the tuberal hypothalamus, a critically important brain region.
    1. Cancer Biology
    2. Developmental Biology

    Bilateral JNK activation is a hallmark of interface surveillance and promotes elimination of aberrant cells

    Deepti Prasad, Katharina Illek ... Anne-Kathrin Classen
    Deregulated cell fate specification pathways, including oncogenic Ras, cause activation of JNK-signaling at contact sites with wild type cells, which drives apoptosis and aberrant cell elimination in a contact-dependent manner.
    1. Developmental Biology
    2. Neuroscience

    Coordinated cadherin functions sculpt respiratory motor circuit connectivity

    Alicia N Vagnozzi, Matthew T Moore ... Polyxeni Philippidou
    A complementary cadherin code is required in phrenic motor neurons and respiratory interneurons to generate robust breathing motor output.
    1. Developmental Biology
    2. Neuroscience

    Dermal appendage-dependent patterning of zebrafish atoh1a+ Merkel cells

    Tanya L Brown, Emma C Horton ... Jeffrey P Rasmussen
    Molecular, cellular, and developmental characterization of zebrafish Merkel cells establishes a new model for the study of mechanosensory epidermal cells.
    1. Developmental Biology
    2. Neuroscience

    Transcription factors underlying photoreceptor diversity

    Juan M Angueyra, Vincent P Kunze ... Wei Li
    Tools and resources to identify transcriptional regulators that create and maintain differences between photoreceptor subtypes.
    1. Cell Biology
    2. Developmental Biology

    Peroxiredoxin 5 regulates osteogenic differentiation through interaction with hnRNPK during bone regeneration

    Eunjin Cho, Xiangguo Che ... Tae-Hoon Lee
    Peroxiredoxin 5 contributes to the maintenance of bone homeostasis by regulating osteoblast differentiation.
    1. Developmental Biology

    MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice

    Greta Rossi, Gabriele Ordazzo ... Vania Broccoli
    The endoplasmic reticulum (ER)-resident protein wolframin regulates MCT1 protein levels in retinal glial cells controlling the shuttling of energy metabolites to both somata and axons of retinal ganglion cells and, thus, supporting their fitness and survival.
    1. Developmental Biology

    Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in flight muscles

    Florian Schueder, Pierre Mangeol ... Frank Schnorrer
    The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.
    1. Developmental Biology

    A nanobody toolbox to investigate localisation and dynamics of Drosophila titins and other key sarcomeric proteins

    Vincent Loreau, Renate Rees ... Dirk Görlich
    A collection of 22 nanobodies against 11 different Drosophila sarcomeric protein epitopes was generated, validated in stainings and for some transgenic fly lines were generated to monitor the dynamics of the sarcomeric proteins in muscles in vivo.