Single-cell transcriptomic analyses of hypothalamic POMC neurons performed at seven developmental ages revealed marked cellular heterogeneity and divergent developmental pathways into alternative neuronal phenotypes that lack POMC.
A novel allele of serum response factor (SRF) reveals distinct co-factor requirements in different developmental contexts, raising issues of redundancy, threshold requirements, or novel co-factor usage.
Research carried out in the simple chordate Ciona has elucidated the regulatory interplay between two evolutionarily conserved transcription factors, Brachyury and Xbp1, and has shed new light on their roles in the formation of the notochord.
Ruth M Williams, Martyna Lukoseviciute ... Marianne E Bronner
A single-cell transcriptomic resource of the early chick epiblast from mid-gastrulation through neurulation highlighting emergence of the neural plate border territory, with emphasis on neural crest specification.
Lucas C Pantaleão, Isabella Inzani ... Susan E Ozanne
Maternal obesity alters the fetal cardiac and serum lipidome, promoting early fetal cardiac metabolic maturation, with evidence that the female heart lipidome is more responsive to an in utero obesogenic environment.
Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.
A simple cryopreservation method using chicken eggs will be a valuable tool to safeguard genetic diversity and conserve the 1600 local breeds of chicken on the planet.
The cargo adapter ARMC2 mediates the association of radial spoke complexes to IFT trains ensuring radial spoke import and assembly in Chlamydomonas flagella.
ZAF (Zebrafish Automated Feeder) is the first fully automated, easy to build, and open source fish feeder designed for small and medium sized labs of which there are an estimated 3250 in 100 countries working with Zebrafish alone today.
