Browse our latest Epidemiology and Global Health articles

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    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Systematic evaluation of multifactorial causal associations for Alzheimer’s disease and an interactive platform MRAD developed based on Mendelian randomization analysis

    Tianyu Zhao, Hui Li ... Li Chen
    A new online data analysis platform, Mendelian Randomization for Alzheimer’s Disease (MRAD), enables the identification of risk or protective factors for Alzheimer’s disease.
    1. Epidemiology and Global Health

    Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal

    Xiaoning Wang, Jinxiang Zhao ... Dong Liu
    Live imaging and single-cell sequencing analyses on zebrafish models revealed that noncaloric monosaccharides and glucose similarly induce excessive blood vessel formation due to endothelial cells' increased formation of tip cells.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Antigenic drift and subtype interference shape A(H3N2) epidemic dynamics in the United States

    Amanda C Perofsky, John Huddleston ... Cécile Viboud
    Antigenic drift in influenza’s major surface proteins, hemagglutinin and neuraminidase, contributes to variability in epidemic magnitude across seasons but is less influential than subtype interference in shaping annual outbreaks.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

    Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee
    Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    Recent evolutionary origin and localized diversity hotspots of mammalian coronaviruses

    Renan Maestri, Benoît Perez-Lamarque ... Hélène Morlon
    The common ancestor of extant mammalian coronaviruses originated recently in a bat species and their diversification occurred via preferential host switches rather than through codiversification with mammals.
    1. Cancer Biology
    2. Epidemiology and Global Health

    Disentangling the relationship between cancer mortality and COVID-19 in the US

    Chelsea L Hansen, Cécile Viboud, Lone Simonsen
    The competing mortality risk from cancer itself overshadows any increase in COVID-19 mortality risk due to cancer.
    1. Epidemiology and Global Health

    Associations of age at diagnosis of breast cancer with incident myocardial infarction and heart failure: A prospective cohort study

    Jie Liang, Yang Pan ... Fanfan Zheng
    Younger age at diagnosis of breast cancer was associated with higher risks of incident myocardial infarction and heart failure.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

    Wei Q Deng, Nathan Cawte ... Sonia S Anand
    Epigenetic signature of maternal smoking contributes to smaller body size and lower birth weight in newborns of European and South Asian ancestry.
    1. Epidemiology and Global Health

    Forecasting the spatial spread of an Ebola epidemic in real-time: comparing predictions of mathematical models and experts

    James D Munday, Alicia Rosello ... Sebastian Funk
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Hybrid immunity from severe acute respiratory syndrome coronavirus 2 infection and vaccination in Canadian adults: A cohort study

    Patrick E Brown, Sze Hang Fu ... Ab-C Study Collaborators
    Population-level hybrid immunity depends substantially on vaccination coverage, including among those previously infected, and dried blood spot collection serves as a practicable biological surveillance platform for these immune responses.