Lineage tracing and genetic analysis in zebrafish show that the pseudobranch is a serial homolog of the gills arising from the jaw-forming mandibular arch, thus supporting the model that vertebrate jaws derived from an ancestral mandibular gill.
Marta Matuszewska, Gemma GR Murray ... Lucy A Weinert
The dominant MRSA circulating in European livestock has stably maintained genes associated with resistance to antibiotic treatments over several decades and when it is transmitted to humans it can rapidly acquire genes that allow it to evade human immune responses.
Jingsong Zhang, Jessica Cunningham ... Robert Gatenby
Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
Ancestral reconstruction of a signaling pathway reveals the mutations responsible for producing specificity of the two paralogous pathways produced by a duplication event.
François Blanquart, Nathanaël Hozé ... Simon Cauchemez
Selection acting on SARS-CoV-2 variants altering the infectivity profile depends on levels of transmission in the community, and this dependence is used to infer Alpha and Delta variants infectivity profiles.
Anastasia V Stolyarova, Tatiana V Neretina ... Georgii A Bazykin
Some deleterious mutations co-occurring within a genome can compensate each other, and this affects patterns of polymorphism, particularly in highly polymorphic species.
New morphological data of a primitive placoderm fish demonstrate both high regionalization of squamation and the bipartite histological structure of scale are plesiomorphic for jawed vertebrates.
