Leo Blondel, Tamsin EM Jones, Cassandra G Extavour
Evidence suggests that the oskar gene, a critical germ line determinant in insects, was formed by fusion of bacterial and eukaryotic sequences at least 450 million years ago.
Unexpected structural diversity of nematode small molecules, as revealed by high-resolution phylogenetic analysis, suggests recurrent biochemical innovation, a pattern that is probably typical across animals.
Joseph L Harman, Andrea N Loes ... Michael J Harms
In the ancestor of mammals, a multifunctional innate immune protein evolved when a mutation enhanced the protein’s pro-inflammatory activity and proteolytic regulation without disrupting the protein’s antimicrobial activity.
Edgar M Medina, Kristyn A Robinson ... Nicolas E Buchler
Spizellomycespunctatusis a genetically tractable chytrid and model organism for comparative cell biology for understanding evolution of the cell cycle, actin dynamics, and cellularization in fungi and early eukaryotes.
Deep mining of GT-A fold sequences provides an evolutionary framework for investigating complex relationships connecting GT-A fold sequence, structure, function and regulation.
Viktor V Feketa, Yury A Nikolaev ... Elena O Gracheva
CNGA3 is a cold-potentiated ion channel that confers cold sensitivity to mouse hypothalamic neurons, whereas CNGA3 from hibernating ground squirrels is cold-insensitive.
Luke Hayden, Katerina Lochovska ... Sophie Pantalacci
The nature and extent of developmental variation seen between mouse strains and genetically identical individuals explain why the first upper molar evolves along preferred path in murine rodents.