Vincent Gardeux, Roel PJ Bevers ... Bart Deplancke
The DGRPool web tool aggregates phenotyping data from the Drosophila Genetic Reference Panel, streamlining genetic association studies and offering new insights into genetic and phenotypic variation in complex traits.
Studies of heterogeneity in healthy brain aging reveal varying susceptibilities to aging and delayed development, which deepen aging-development understanding and promote prediction and diagnosis of cognitive decline and neurodegenerative diseases.
Alon Avraham Ginatt, Maria Berihu ... Shiri Freilich
Understanding metabolic interactions and successive cross-feeding in native microbiomes illuminates the mechanisms behind plant disease promotion and suppression, enhancing our ability to manipulate microbiomes toward specific functions of interest.
Monosomy in yeast results in numerous gene dosage insufficiencies with potentially lethal collective effect, but strong positive epistasis rooted in the modular structure of cell metabolism cancels it.
Yi-Ting Tsai, Nogayhan Seymen ... Mohammad M Karimi
Despite no observed correlation between retrotransposon (RTE) activity and chronological age, the expression of most RTE classes and families except SINEs correlated with biological age-associated gene signature scores.
Archana Kamalakar, Brendan Tobin ... Steven L Goudy
Innovative JAGGED1-based therapies show promise for pediatric craniofacial bone loss, potentially overcoming limitations of current treatments with more effective and accessible solutions.
The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.
A new online data analysis platform, Mendelian Randomization for Alzheimer’s Disease (MRAD), enables the identification of risk or protective factors for Alzheimer’s disease.
