Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

    Jessica Gray, Von Vergel L Torres ... Ian R Henderson
    Klebsiella pneumoniae has specific repertoires of genes required for growth in urine and serum, highlighting new targets for antimicrobial treatments of this important pathogen.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A single-cell atlas of the miracidium larva of Schistosoma mansoni reveals cell types, developmental pathways, and tissue architecture

    Teresa Attenborough, Kate A Rawlinson ... Matthew Berriman
    A comprehensive description of gene expression and organisation in the cells that constitute the blood fluke larvae responsible for finding and invading its intermediate host.
    1. Developmental Biology
    2. Genetics and Genomics

    The role of heterochronic gene expression and regulatory architecture in early developmental divergence

    Nathan D Harry, Christina Zakas
    Changes in the amount and timing of gene expression during early development contribute to evolutionary divergence and life-history changes, even within a species.
    1. Developmental Biology
    2. Genetics and Genomics

    sisterless A is required for activation of Sex lethal in the Drosophila germline

    Raghav Goyal, Ellen Baxter, Mark Van Doren
    Not revised
    Reviewed Preprint v1
    • Useful
    • Convincing
    • Incomplete
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry

    Wei Q Deng, Nathan Cawte ... Sonia S Anand
    Epigenetic signature of maternal smoking contributes to smaller body size and lower birth weight in newborns of European and South Asian ancestry.
    1. Cancer Biology
    2. Genetics and Genomics

    Circulating small extracellular vesicle RNA profiling for the detection of T1a stage colorectal cancer and precancerous advanced adenoma

    Li Min, Fanqin Bu ... Shutian Zhang
    Whole-transcriptomic profiling of circulating small extracellular vesicle RNA facilitates the detection of T1a stage colorectal cancer and precancerous advanced adenoma.
    1. Cell Biology
    2. Genetics and Genomics

    Impact of Maximal Overexpression of a Non-toxic Protein on Yeast Cell Physiology

    Yuri Fujita, Shotaro Namba, Hisao Moriya
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Non-cognate immunity proteins provide broader defenses against interbacterial effectors in microbial communities

    Abigail Knecht, Denise Sirias ... Karine A Gibbs
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Genetics and Genomics

    Deficiency of IQCH causes male infertility in humans and mice

    Tiechao Ruan, Ruixi Zhou ... Ying Shen
    IQCH is required for acrosome and axoneme development during spermatogenesis in humans and mice.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Discovery of runs-of-homozygosity diplotype clusters and their associations with diseases in UK Biobank

    Ardalan Naseri, Degui Zhi, Shaojie Zhang
    ROH-DICE is an efficient method for detecting ROH clusters in biobank data, enabling the study of population history of large cohorts, and providing a new genome-wide association analysis approach for finding disease-causing loci with multi-marker recessive effects.
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