Browse our latest Genetics and Genomics articles

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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Regulatory genome annotation of 33 insect species

    Hasiba Asma, Ellen Tieke ... Marc S Halfon
    Over 2.8 million tissue-specific gene regulatory sequences are predicted for 33 insect genomes, using a simple computational workflow with only the genome sequence and a basic gene annotation as input.
    1. Developmental Biology
    2. Genetics and Genomics

    Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction

    Morgane Djebar, Isabelle Anselme ... Christine Vesque
    Brain ventricular astrogliosis and neuroinflammation precede scoliosis onset in the zebrafish rpgrip1l ciliary mutant and anti-inflammatory treatment drastically reduces scoliosis while correcting urotensin related peptide level is ineffective.
    1. Cancer Biology
    2. Genetics and Genomics

    Gene Fusion: Decoding the identity of rare tumors

    Qingchen Yuan, Prabhjot Kaur, Olga A Guryanova
    Solitary fibrous tumors have gene expression signatures similar to those of neuroendocrine tumors.
    Version of Record
    Insight
    1. Genetics and Genomics

    Novel risk loci for COVID-19 hospitalization among admixed American populations

    Silvia Diz-de Almeida, Raquel Cruz ... Ángel Carracedo
    Genetic association analyses in Latin American individuals revealed two additional loci associated with COVID-19 that were not previously found in other population groups.
    1. Genetics and Genomics

    An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis

    Jake D Lehle, Yu-Huey Lin ... John R McCarrey
    The utility of an in vitro cell culture system for studies of molecular mechanisms underlying the initial induction and subsequent propagation of environmentally induced epimutations is demonstrated.
    1. Genetics and Genomics

    Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

    Shaohua Gu, Yuanzhe Shao ... Zhiyuan Li
    A novel bioinformatic pipeline predicts diverse pyoverdine structures and receptor groups with high accuracy, revealing significant hidden diversity in siderophores systems across Pseudomonas genomes.
    1. Cancer Biology
    2. Genetics and Genomics

    Patient-derived xenografts and single-cell sequencing identifies three subtypes of tumor-reactive lymphocytes in uveal melanoma metastases

    Joakim W Karlsson, Vasu R Sah ... Jonas A Nilsson
    Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

    Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee
    Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
    1. Genetics and Genomics

    Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    Wenjing Liu, Shujin Li ... Xianjun Zhu
    Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

    Catherine A Weibel, Andrew L Wheeler ... Joanna Masel
    Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.