Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics
    2. Medicine

    Single-cell characterization of menstrual fluid at homeostasis and in endometriosis

    Petra C Schwalie, Cemsel Bafligil ... Angela Goncalves
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cell Biology
    2. Genetics and Genomics

    Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

    Breanna Lam, Kathrin M Kajderowicz ... Sinisa Hrvatin
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Functional characteristics and computational model of abundant hyperactive loci in the human genome

    Sanjarbek Hudaiberdiev, Ivan Ovcharenko
    Large-scale multi-omics analysis of genomic high-occupancy target regions in humans suggests involvement of large transcriptional condensates.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic

    Michael James Chambers, Sophia B Scobell, Meru J Sadhu
    The innate immune protein PKR, which is inhibited by viral proteins that mimic its natural substrate, has access to a wide spectrum of inhibitor-evading mutations that maintain natural substrate binding.
    1. Genetics and Genomics

    An ancient competition for the conserved branchpoint sequence influences physiological and evolutionary outcomes in splicing

    Karen Larissa Pereira de Castro, Jose M Abril ... W Samuel Fagg
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Evolutionary Biology
    2. Genetics and Genomics

    Archaic introgression contributed to shape the adaptive modulation of angiogenesis and cardiovascular traits in human high-altitude populations from the Himalayas

    Giulia Ferraretti, Paolo Abondio ... Marco Sazzini
    A combination of composite-likelihood and gene network-based methods to investigate the impact of Denisovan introgression on the evolution of complex (i.e., polygenic) adaptive traits in high-altitude populations of Tibetan/Sherpa ancestry.
    1. Genetics and Genomics
    2. Neuroscience

    Characterizing the Spatial Distribution of Dendritic RNA at Single Molecule Resolution

    Jihoon Kim, Jean G Rosario ... Junhyong Kim
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Cancer Biology
    2. Genetics and Genomics

    Cancer: Predicting drug resistance

    Nicole S Arellano, Shannon E Elf
    A new approach helps examine the proportion of cancerous and healthy stem cells in patients with chronic myeloid leukemia and how this influences treatment outcomes.
    Version of Record
    Insight
    1. Cancer Biology
    2. Genetics and Genomics

    Single-cell multiomics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response

    Rebecca Warfvinge, Linda Geironson Ulfsson ... Göran Karlsson
    Single-cell analysis of CML patients bone marrow at diagnosis reveals coexistence of CD26-CD35+ healthy stem cells and CD26+CD35- CML stem cells, and how the ratio between these impacts TKI response.
    1. Genetics and Genomics

    DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice

    Xiang Wang, Gan Shen ... Ying Shen
    DNAH3 is a novel pathogenic gene of male infertility and plays essential role in flagellar IDA assembly in humans and mice.
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